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MetabolomicsUntargeted Metabolomics Reveals a Lack Of Synergy between Nifurtimox and Eflornithine against Trypanosoma brucei
A non-targeted metabolomics-based approach is presented that enables the study of pathways in response to drug action with the aim of defining the mode of action of trypanocides. Eflornithine, a polyamine pathway inhibitor, and nifurtimox, whose mode of action involves its metabolic activation, are ...
2017-06-07 | MTBLS459 | MetaboLights
TranscriptomicsMicroarray expression data from human renal mesangial cells (HMC) treated with a Cyclosporine A (CsA) time course.
HMCs were treated with CsA (4.2 M-BM-5M) for 0 12 and 48 hours. To exmaine global gene changes in the renal mesangium following CsA treatment in order to identify novel contributors to CsA-induced renal dysfunction Microarray analysis was used to identify novel mechanisms of CsA nephrotoxicity in th...
ORGANISM(S): Homo sapiens 
2012-04-03 | E-GEOD-30952 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of flax stems and leaves from 4 week old flax plants to identify transcripts enriched in stem and phloem bast fibres
Stems and leaves from 4 week old flax plants were hybridized to an array of cDNAs from the outer (i.e. phloem enriched) layer of stems of the same age to identify transcripts enriched in stem (and phloem bast fibres).
ORGANISM(S): Linum usitatissimum 
2007-05-01 | E-MEXP-989 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of flax (Linum usitatissimum) developmental series
Three 2cm segments were excised from different parts (TOP, MID, BOT) along the vertical axis of a 4 week old (25cm) stem of flax (L. usitatissimum) were compared using a cDNA amplicon array. Each segment represented a different developmental stage, especially in relation to bast fibre differentia...
ORGANISM(S): Linum usitatissimum 
2007-05-01 | E-MEXP-990 | biostudies-arrayexpress
ProteomicsDisruption of ClpX reverts fluconazole susceptibility for Cryptococcus neoformans through modified heme biosynthesis and ergosterol production
Fungal disease impacts the lives of almost a billion people across the globe. The opportunistic human fungal pathogen, Cryptococcus neoformans, causes cryptococcal meningitis in immunocompromised individuals with high fatality rates in response to limited treatment options. Moreover, the emergence o...
ORGANISM(S): Fungi Cryptococcus neoformans var. grubii 
2025-07-04 | PXD052366 | Pride
Clpx Cryptococcus neoformans Ergosterol Heme Antifungal resistance Quantitative proteomics Fluconazole 
ProteomicsAssessing protein sequence database suitability using de novo sequencing
The analysis of samples from unsequenced and/or understudied species as well as samples where the proteome is derived from multiple organisms poses two key questions. The first is whether the proteomic data obtained from an unusual sample type even contains peptide tandem mass spectra. The second ...
ORGANISM(S): glacier metagenome Hydrolagus colliei Diaphorina citri (Asian citrus psyllid) Homo sapiens (Human) marine metagenome Ursus deningeri Caenorhabditis elegans Leucoraja erinacea 
2019-11-20 | PXD015083 | Pride
Fasta Proteomics Metaproteomics 
TranscriptomicsTranscription profiling by array of Arabidopsis mutant for abi1, aba1, max4, axr1, AtMYB50 or AtMYB61
Plants that exhibit secondary growth, such as trees, are a prominent feature of terrestrial ecosystems. Furthermore, secondary growth itself, particularly wood, has huge economic value. Despite the importance of secondary growth from both basic and applied science perspectives, little is known abou...
ORGANISM(S): Arabidopsis thaliana 
2008-06-14 | E-GEOD-6151 | biostudies-arrayexpress
TranscriptomicsA novel recurrent mutation in MITF predisposes to familial and sporadic melanoma
We identified a novel germline mutation of the microphthalmia-associated transcription factor (MITF - E318K). This mutation was found to be present in numerous melanoma families, as well as the general population, where its association with melanoma has a significant effect. We determined the effe...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-31269 | biostudies-arrayexpress
UnknownPeripheral blood cytokine profiles predict the severity of SARS-CoV-2 infection: an EPIC<sup>3</sup> study analysis.
Not available
S-EPMC12063214 | biostudies-literature
UnknownSimvastatin in Critically Ill Patients with Covid-19.
Not available
S-EPMC10755839 | biostudies-literature
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