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MetabolomicsSynovial Fluid Metabolites Differentiate between Septic and Nonseptic Joint Pathologies
Osteoarthritis (OA), osteochondrosis (OC), and synovial sepsis in horses cause loss of function and pain. Reliable biomarkers are required to achieve accurate and rapid diagnosis, with synovial fluid (SF) holding a unique source of biochemical information. Nuclear magnetic resonance (NMR) spectrosco...
2018-07-20 | MTBLS543 | MetaboLights
ProteomicsProteome of paediatric burn wound fluid collected via negative pressure wound therapy
Negative pressure wound therapy (NPWT) has been used to promote wound healing in a variety of settings, including as an adjunct to silver-impregnated dressings in the acute management of paediatric burns. Fluid aspirated by the NPWT system represents a potentially insightful research matrix for unde...
ORGANISM(S): Homo sapiens (Human) 
2021-01-04 | PXD023168 | Pride
Exudate Proteomics Swath Paediatric Effluent Npwt Oedema fluid Burn Blister fluid Lc-ms/ms 
ProteomicsProteome of paediatric burn wound fluid collected via negative pressure wound therapy
Negative pressure wound therapy (NPWT) has been used to promote wound healing in a variety of settings, including as an adjunct to silver-impregnated dressings in the acute management of paediatric burns. Fluid aspirated by the NPWT system represents a potentially insightful research matrix for unde...
ORGANISM(S): Homo sapiens (Human) 
2022-08-15 | PXD023161 | Pride
Exudate Proteomics Swath Paediatric Effluent Npwt Oedema fluid Burn Blister fluid Lc-ms/ms 
MetabolomicsUntargeted Metabolomics of the enthesis interstitial fluid of wild-type and Nlrp3-/- mice with sham operation and injury post 7 days
In order to investigate the effect of the NLRP3 inflammasome on the regeneration of enthesis, we established an enthesis injury and repair model in wild-type and NLRP3-/- mice. The interstitial fluid of enthesis was extracted, and untargeted metabolomics was conducted to discover differential metabo...
2025-07-08 | MTBLS12150 | MetaboLights
ProteomicsBioinformatic analysis of the wound peptidome reveals potential biomarkers and antimicrobial peptides
Peptidomic analysis and methodological development of characterization of low molecular weight peptidome of human wound fluids. Wounds are dynamic environments with high proteolytic activity. Therefore, the study of peptides, being the degradational product of proteins, are of interest when diagnosi...
ORGANISM(S): Homo sapiens (Human) 
2021-01-18 | PXD023244 | Pride
Peptidomics wound fluid 
ProteomicsBlinded rerun of infected and uninfected pig wound fluids
This is a blinded rerun of 12 pig wound fluid samples from the study at PXD048892, looking at differences in wound fluid peptidomes based on infecting pathogen.The raw data alongside code for easily loading and processing the data and creating relevant figures is available at https://github.com/Fred...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-05-13 | PXD055074 | Pride
Wound fluid Proteomics Infection Porcine Pig 
ProteomicsQuantitative proteomic characterization of Foreign Body Response towards silicone breast implants identifies chronological disease-relevant biomarker dynamics
The aim of this work was to enlighten the disease progression from implant insertion and immediate tissue damage response reflected in (a) the acute wound proteome, and (b) the adsorption of chronic inflammatory wound proteins at implant surfaces. An intra-individual relative quantitation TMT-liquid...
ORGANISM(S): Homo sapiens (Human) 
2023-02-24 | PXD039840 | Pride
Smi (silicone mammary implants)  fbr (foreign body response)  wound healing  wound infection  capsular fibrosis  implant encapsulation  early-stage fibrosis  surface adsorption  immunomics  biomarkers 
ProteomicsComparative degradomics of porcine and human wound exudates unravels biomarker candidates for assessment of wound healing progression in trauma patients
Impaired cutaneous wound healing is a major complication in elderly people and patients suffering from diabetes with raising rates in industrialized countries. Heterogeneity of clinical manifestations hampers effective molecular diagnostics and decisions for appropriate therapeutic regimens. Using a...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2017-09-14 | PXD006674 | Pride
Impaired wound healing Negative pressure wound therapy Positional proteomics Tails Wound fluids Biomarker 
ProteomicsIn Vivo Assessment of Protease Dynamics in Cutaneous Wound Healing by Degradomics Analysis of Porcine Wound Exudates
Proteases control complex tissue responses by modulating inflammation, cell proliferation and migration, and matrix remodeling. All these processes are orchestrated in cutaneous wound healing to restore the skin’s barrier function upon injury. Altered protease activity has been implicated in the p...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2014-12-19 | PXD001198 | Pride
N-terminome Wound healing Protease Tails Wound fluids 
ProteomicsLLS7(P)-M-NPs Protein Corona Characterization
Characterization of LLS7(P)-M-NPs protein corona in SWF (Simulated Wound Fluid) matrix.
ORGANISM(S): Bos taurus (Bovine) 
2025-10-26 | PXD058949 | Pride
Protein corona Nanoparticles Simulated wound fluid 
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