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ProteomicsExoproteome profiling reveals the involvement of the foldase PrsA in the cell surface properties and pathogenesis of S. aureus
Staphylococcus aureus is a bacterial pathogen that produces and exports many virulence factors that cause human diseases. PrsA, a membrane-bound foldase that is found ubiquitously in Gram-positive bacteria, is required for the folding of exported proteins into a stable and active structure. However,...
ORGANISM(S): Staphylococcus aureus 
2018-01-24 | PXD008528 | Pride
Prsa Itraq S. ureus 
ProteomicsiTRAQ-based identification of oral cancer progression-related proteins with tumor tissues from oral cancer patients and patient-derived xenograft mouse models
In Taiwan, oral cancer has been the fourth leading cause of cancer-related deaths in men for at least a decade. Clinical statistics show that approximately 95% of all oral cancer cases are oral cavity squamous cell carcinoma (OSCC). Patients diagnosed with advanced-stage OSCC often present with cerv...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD046930 | Pride
Patient-derived xenografts Proteomics Tumor tissue Itraq Oral cavity squamous cell carcinoma 
ProteomicsIdentification of dysregulated proteins in primary and relapsed oral cancer tissues with iTRAQ-based mass spectrometry
Oral cancer is the sixth leading cause of the cancer-related mortality in Taiwan. More than 90% of oral cancers are oral cavity squamous cell carcinomas (OSCCs). The high mortality rate of OSCC is ascribed to metastasis and local regional relapse of cancer cells, suggesting that identification of pr...
ORGANISM(S): Homo sapiens (Human) 
2025-06-04 | PXD046780 | Pride
Proteomics Tumor tissue Itraq Oral cavity squamous cell carcinoma Relapse 
ProteomicsIdentification of salivary biomarkers for oral cancer with quantitative proteomics and two-phase verifying approaches
Oral cavity cancer is one of the most common cancer worldwide and oral cavity squamous cell carcinoma (OSCC) accounts for up to 90 percent of oral cancers. In Taiwan, OSCC is the fifth most common malignancy of male and causes more than 250 deaths per year. The poor outcome of OSCC patients is princ...
ORGANISM(S): Homo sapiens (Human) 
2019-08-15 | PXD008655 | Pride
Salivary biomarker Oral cancer Mrm-ms Elisa Quantitative proteomics 
ProteomicsiTRAQ-based MS analysis of nasopharyngeal carcinoma cells with inflammasome activation
We previously reported that tumor-cell inflammasomes play a key role in tumor control and act as favorable prognostic markers in nasopharyngeal carcinoma (NPC). Activated inflammasomes frequently form distinguishable ASC specks and govern the cellular secretion of IL-1. However, we know little about...
ORGANISM(S): Homo sapiens (Human) 
2019-11-15 | PXD013071 | Pride
Nasopharyngeal carcinoma Inflammasome Itraq Mitochondrial oxidative phosphorylation 
ProteomicsIdentification of salivary autoantibodies as biomarkers of oral cancer with IgA enrichment combined with affinity mass spectrometry
Globally, oral cavity squamous cell carcinoma (OSCC) is one of the most common fatal illnesses. Its high mortality is ascribed to the fact that the disease is often diagnosed at a late stage, which indicates an urgent need for approaches for the early detection of OSCC. The use of salivary autoantib...
ORGANISM(S): Homo sapiens (Human) 
2025-06-04 | PXD036897 | Pride
Autoantibody Proteomics Saliva Biomarker Oral cavity squamous cell carcinoma 
ProteomicsProteomic profiling of paired interstitial fluids revealed dysregulated pathways and salivary NID1 as a biomarker of oral cavity squamous cell carcinoma
Patients with oral cavity squamous cell carcinoma (OSCC) are frequently first diagnosed at an advanced stage, leading to poor prognosis and high mortality rate. Early detection of OSCC using body fluid-accessible biomarkers may help improve the prognosis and survival rate of OSCC patients. As tumor ...
ORGANISM(S): Homo sapiens (Human) 
2019-08-15 | PXD008654 | Pride
Tumor interstitial fluid Saliva Oral cavity squamous cell carcinoma Aminoacyl trna biosynthesis Nidogen-1 Biomarker 
ProteomicsIdentification of components in protein complex of influenza A virus PA protein
Influenza A virus is mainly transmitted through the respiratory route and can cause severe illness in humans. Proteins encoded by influenza A virus can interact with cellular factors and dysregulate host biological processes to facilitate viral replication and pathogenicity. The influenza viral PA p...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050585 | Pride
Spectral counting-based quantification Polymerase acidic protein (pa) Interactome Influenza a virus 
ProteomicsSecretome profiling of canine mammary tumor cells reveals AGR2-mediated regulation of protein secretion
Canine mammary tumors (CMTs) in intact female dogs serve as a valuable natural model for understanding human cancers. Our previous findings identified the overexpression of Anterior Gradient 2 (AGR2) in CMT tissues compared to normal mammary glands, highlighting its association with CMT progression....
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2024-06-16 | PXD047008 | Pride
Canine mammary tumor (cmt) Secretome Label-free quantification Anterior gradient 2 (agr2) 
UnknownThe 10-Year Prognosis and Prevalence of Brugada-Type Electrocardiograms in Elderly Women: A Longitudinal Nationwide Community-Based Prospective Study.
Not available
S-EPMC7553189 | biostudies-literature
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