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ProteomicsTargeting an atypical G protein–coupled receptor signalingpathway for cardiacfibrosis therapy
Cardiac fibrosis independently predicts adverse outcomes in heart failure (HF), yet no Food and Drug Administration–approved therapy directly targets fibrotic remodeling in the heart. To address this unmet clinical need, we used a multidimensional drug discovery pipeline centered on a human induced ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-27 | PXD054513 | Pride
Therapy Cardiac fibrosis Gpcr signaling 
ProteomicsHsp40 Affinity Profiling Identifies the Unique Cellular Protein Destabilization Profile Induced by Exposure to Chloroacetamide Herbicides
We applied TMT-AP-MS to determine changes in Flag-DNAJB8-H31Q interactors in HEK293T cells upon treatment with acetochlor, alachlor, and propachlor. We also looked into aggregation in HEK293T cells after propachlor treatment.
ORGANISM(S): Homo sapiens (Human) 
2022-07-05 | PXD030635 | Pride
Human Ap-ms Aggregation Hsp40 Dnjab8 Chloroacetanilide herbicides 
TranscriptomicsTranscriptome Alteration in the Diabetic Heart by Rosiglitazone: Implications for Cardiovascular Mortality
The type 2 diabetes medication, rosiglitazone, has come under scrutiny for possibly increasing the risk of cardiac disease and death. To investigate the effects of rosiglitazone on the diabetic heart, we performed cardiac transcriptional profiling of a murine model of type 2 diabetes, the C57BL/KLS...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-36875 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of inter- and intra-patient variation in human iPSC cardiomyocytes: Platform for precision medicine to predict drug toxicity
In the present study we created and analyzed cardiomyocytes from two separate iPSC clones from the fibroblasts of five different female individuals and two male individuals, using footprint-free Sendai virus RNA-seq of iPSC cardiomyocytes, Ampli-seq of heart left ventricle and iPSC cardiomyocytes (w...
ORGANISM(S): Homo sapiens 
2016-08-24 | E-GEOD-83668 | biostudies-arrayexpress
UnknownEffectiveness of Smartphone-Based Community Case Management on the Urgent Referral, Reconsultation, and Hospitalization of Children Aged Under 5 Years in Malawi: Cluster-Randomized, Stepped-Wedge Trial.
Not available
S-EPMC8567152 | biostudies-literature
UnknownHIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus.
Not available
S-EPMC7598056 | biostudies-literature
MetabolomicsClock regulation of metabolites reveals coupling between transcription and metabolism
The circadian clock is intricately connected with metabolism, however the precise details of these connections are incomplete. Here we used high temporal resolution metabolite profiling to determine circadian regulation of mouse liver and cell autonomous metabolism. In mouse liver, we found ~50% of ...
2017-04-05 | MTBLS292 | MetaboLights
UnknownAncestral sequence reconstruction pinpoints adaptations that enable avian influenza virus transmission in pigs.
Not available
S-EPMC8557130 | biostudies-literature
GenomicsGenome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis

Monozygotic (MZ) twins have been widely employed for dissection of the relative contributions of genetics and environment in disease. In multiple sclerosis (MS), an autoimmune demyelinating disease that commonly causes neurodegeneration and disability in young adults, disease discordance in M...

phs000239.v2.p1 | EGA
UnknownEffect of Sickle Cell Trait and APOL1 Genotype on the Association of Soluble uPAR with Kidney Function Measures in Black Americans.
Not available
S-EPMC7863645 | biostudies-literature
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