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MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
MetabolomicsSupplementation of Bacillus sp. DU-106 reduces hypercholesterolemia and ameliorates gut dysbiosis in high-fat diet rats

Gut microbiota modulation by a probiotic is a novel therapy for hypercholesterolemia mitigation. This study initially investigated the potential hypocholesterolemic effect of Bacillus sp. DU-106 in hypercholesterolemic rats and explored its potential relation with gut microbiota. Sprague-Dawley r...

2021-04-08 | MTBLS1168 | MetaboLights
UnknownAssociation between TyG index and long-term mortality of critically ill patients: a retrospective study based on the MIMIC Database.
Not available
S-EPMC10230925 | biostudies-literature
MetabolomicsSaliva metabolome and microbiome in permanent teeth caries

Metabolites are important determinants of disease progression. In this study, we conducted a case-control study to explore permanent teeth caries-related differences in salivary metabolite profiles and related changes in the composition of the oral microbiota in 200 subjects including 100 caries-...

2024-05-14 | MTBLS4569 | MetaboLights
ProteomicsIP-MS detected the interation proteins of PHGDH
Vascular endothelial cells (ECs) senescence correlates with the increase of cardiovascular diseases in ageing population. Although ECs rely glycolysis for energy production, little is known about the role of glycolysis in ECs senescence. Here, we report a critical role for glycolysis-derived serine ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD035586 | Pride
Mass spectrometry Phgdh Co-immunoprecipitation 
ProteomicsIP-MS detected the interation protein with PKM2
Vascular endothelial cells (ECs) senescence correlates with the increase of cardiovascular diseases in ageing population. Although ECs rely glycolysis for energy production, little is known about the role of glycolysis in ECs senescence. Here, we report a critical role for glycolysis-derived serine ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD035585 | Pride
Co-immunoprecipitation Pkm2 
ProteomicsSaccharomyces cerevisiae LC-MSMS
IP-MS detection of proteins pulled down by Glc7-FLAG by mass spectrometry
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-10-24 | PXD036005 | Pride
Lc-msms Saccharomyces cerevisiae 
UnknownFlavonoids profile and antioxidant capacity of four wine grape cultivars and their wines grown in the Turpan Basin of China, the hottest wine region in the world.
Not available
S-EPMC11907473 | biostudies-literature
ProteomicsHuman CCDC114-mutant patient derived air-liquid interface (ALI) organoids proteome
In this experiment we investigate the different expressed proteins between healthy control ALI organoids and CCDC114-mutant ALI organoids.
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD064456 | Pride
Human Organoids Airway Ccdc114 
UnknownA Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19.
Not available
S-EPMC7121492 | biostudies-literature
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