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ProteomicsSEC23B-dependent COPII Vesicles Regulate T Cell Immunity
The coordinated release of proteins by T cells enables controlled biological responses. While the molecular mechanisms underlying T cell secretion are being increasingly understood, whether the critical ER-to-Golgi trafficking pathway regulates T cell immunity is not known. We utilized mice with a T...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD015766 | Pride
Lc-msms Lymphocytes Mouse 
ProteomicsProximity labeling of Siglec-1 counter-receptors on activated regulatory T cells using soluble Siglec-1-HRP multimers
Siglec-1 is a macrophage lectin-like receptor that mediates sialic acid-dependent cellular interactions. It was shown previously to promote inflammation in autoimmune disease through suppressing the expansion of regulatory T cells (Tregs). We have investigated the molecular basis for Siglec-1 bindin...
ORGANISM(S): Armoracia rusticana Mus musculus (Mouse) Homo sapiens (Human) 
2021-04-28 | PXD021693 | Pride
Proximity labeling Counter-receptor Siglec-1 
ProteomicsProximity labeling of Siglec-1 counter-receptors on activated regulatory T cells using Siglec-1-HRP multimers on nano-beads
Siglec-1 is a macrophage lectin-like receptor that mediates sialic acid-dependent cellular interactions. It was shown previously to promote inflammation in autoimmune disease through suppressing the expansion of regulatory T cells (Tregs). We have investigated the molecular basis for Siglec-1 bindin...
ORGANISM(S): Armoracia rusticana Mus musculus (Mouse) Homo sapiens (Human) 
2021-04-28 | PXD021691 | Pride
Proximity labeling Counter-receptor Siglec-1 
ModelsWu2011 - Influenza-specific CD8+ T cells
No description
2016-02-10 | MODEL1504160000 | BioModels
UnknownSkeletal muscle antagonizes antiviral CD8+ T cell exhaustion.
Not available
S-EPMC7292629 | biostudies-literature
ProteomicsMass spectrometry analysis of proteins interacting with Fbxw7 in T cells
To elucidate how gut microbiota (GM) downregulated Fbxw7, we treated CD4+ T cells with GM-lysates and pulled down Fbxw7 in the cell lysates. Then, the precipitated proteins were analyzed by mass spectrometry, and eight E3 ligases were revealed to interact with Fbxw7.
ORGANISM(S): Mus musculus (Mouse) 
2025-04-16 | PXD057140 | Pride
Fbxw7  trim21  th17 cells  gut microbiota 
ProteomicsFAM135B deficiency inhibits cytotoxic T cell activity in triple-negative breast cancer by blocking the IFI16-dependent STING pathway
FAM135B interacts with IFI16, inhibiting its ubiquitination and proteasomal degradation by competitively blocking its binding to the E3 ligase TRIM21, thereby initiating the IFI16-dependent STING signaling, ultimately leading to increased cytotoxic T cell activity.
ORGANISM(S): Homo Sapiens 
2025-09-09 | PXD068216 |
ProteomicsN-glycosylated LTβR increases the Th17/Treg cell ratio in liver cancer by blocking RORC ubiquitination and FOXP3 transcription
Proteins binding to PELI1 and TRAF3 were identified by protein profiling
ORGANISM(S): Mus Musculus 
2025-04-08 | PXD062760 |
GenomicsHomo sapiens strain:CD4+ T-Cells
HIV integration in latent and active human CD4-positive t-cells
PRJNA213846 | ENA
GenomicsITK Degradation to Block T-cell Receptor Signaling and Overcome Therapeutic Resistance in T-Cell Lymphomas
ITK Degradation to Block T-cell Receptor Signaling and Overcome Therapeutic Resistance in T-Cell Lymphomas
PRJNA938918 | ENA
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