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ProteomicsMechanism of beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy
Beta-arrestins (βarrs) are key regulators and transducers of G-protein coupled receptor signaling; however, little is known of how βarrs communicate with their downstream effectors. Here, we report the first structural insights into the fundamental mechanisms driving βarr-mediated signal transductio...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2026-01-27 | PXD073058 | Pride
Src activation Beta-arrestin Cxms Src Lc-ms/ms 
ProteomicsPrecision in Tear Fluid Biomarker Discovery: Quantitative Proteomic Profiling of Small-Volume, Individual Samples Using Capillary Tube Collection
Tear fluid, a complex biofluid that contains thousands of proteins and can be collected non-invasively, has emerged as a promising source of biomarkers for ocular and systemic health. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is currently the primary method for discovering novel biom...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD060101 | Pride
1. tear proteomics  2. tear biomarker  3. biomarker discovery  4. capillary collection  5. lc-ms/ms 
ProteomicsDiagnosis of T-cell-mediated kidney rejection by biopsy-based proteomic biomarkers and machine learning
Background: Biopsy-based diagnosis is essential for maintaining renal allograft longevity by ensuring prompt treatment for graft complications. Although histologic assessment remains the gold standard, it carries significant limitations such as subjective interpretation, suboptimal reproducibility, ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-01 | PXD038601 | Pride
Machine learning Kidney transplantation Mass spectrometry Ffpe Diagnosis Biomarker Quantitative proteomics 
ProteomicsProteomics characterization of human peritoneal tissue
To identify the proteome of human peritoneal tissue, 43 FFPE and 5 fresh frozen peritoneal tissue samples at healthy or non-cancerous state were collected and subjected to mass spectrometry analysis. The resulting findings represnt a baseline catalog of the proteomic composition of the peritoneum, a...
ORGANISM(S): Homo sapiens (Human) 
2025-12-31 | PXD071403 | Pride
Human Peritoneum Lc-ms/ms 
ProteomicsVariation in Plasma Proteome Associated with Delayed Blood Processing
Variations in pre-analytical processing of plasma samples can potentially result in different proteomic profiles identifed by downstream analyses. Here, we investigated the effects of delayed blood processing for up to eight hours on the observed plasma protein groups by tandem mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD060901 | Pride
Human Lc-msms Plasma 
UnknownMARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β2-adrenergic receptors
Not available
S-JCBD-201208192 | bioimages
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