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UnknownPhase I clinical trial of a novel procaspase-3 activator SM-1 with temozolomide in recurrent high-grade gliomas.
Not available
S-EPMC11879598 | biostudies-literature
ProteomicsMetabolite-protein covariation architecture identifies a cysteine shunt regulating liver cholesterol
Protein regulation of metabolic processes is foundational to biology. Here we develop a mass spectrometry-based approach that leverages genetic diversity to nominate functional relationships between 285 metabolites and 11,868 proteins in living tissues. This Metabolite Protein Covariation Architectu...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-28 | PXD065355 | Pride
Lrrc58 Metabolism Cdo1 Do mice Cysteine Lasso Proteomics 
ProteomicsA Fkh1/2 binding site array in the WHI5 promoter drives sub-scaling transcription
Cells typically regulate their size within a relatively tight range by coupling growth to the cell division cycle using a dedicated set of molecular mechanisms. In budding yeast, cells are born with a similar amount of the G1/S inhibitor protein Whi5 that is then diluted by growth throughout G1. As ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-03-31 | PXD075635 | Pride
Whi5 Cell size Size scaling 
MetabolomicsChanges in the Milk Metabolome of the Giant Panda (Ailuropoda melanoleuca) with Time after Birth – Three Phases in Early Lactation and Progressive Individual Differences
Ursids (bears) in general, and giant pandas in particular, are highly altricial at birth. The components of bear milks and their changes with time may be uniquely adapted to nourish relatively immature neonates, protect them from pathogens, and support the maturation of neonatal digestive physiology...
2015-03-31 | MTBLS165 | MetaboLights
TranscriptomicsGenome-wide analysis of histone modification, protein-DNA binding, cytosine methylation and transcriptome data in mouse and human ES cells and pig iPS cells
Genome-wide analysis of histone modification (H2AZ, H3K27ac, H3K27me3, H3K36me3, H3K4me1, H3K4me2, H3K4me3 and H3K9me3), protein-DNA binding (TAF1, P300, Pou5f1 and Nanog), cytosine methylation and transcriptome data in mouse and human ES cells and pig iPS cells We generated histone modification da...
ORGANISM(S): Homo sapiens 
2012-02-28 | E-GEOD-36114 | biostudies-arrayexpress
ProteomicsLactate regulates cell cycle and proliferation by remodeling the anaphase promoting complex
Lactate is abundant in rapidly dividing cells, due to the requirement for elevated glucose catabolism to support proliferation. However, it is not known whether accumulated lactate affects the proliferative state. Here, we deploy a systematic approach to determine lactate-dependent regulation of pro...
ORGANISM(S): Homo sapiens (Human) 
2023-02-07 | PXD036641 | Pride
Tpp Lactate Cell cycle 
UnknownA Fkh1/2 binding site array in the <i>WHI5</i> promoter drives sub-scaling transcription.
Not available
S-EPMC12632407 | biostudies-literature
UnknownSex-specific effects of exercise ancestry on metabolic, morphological and gene expression phenotypes in multiple generations of mouse offspring.
Not available
S-EPMC3783594 | biostudies-literature
GenomicsGenome wide association study of leprosy in Chinese population

Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae). Due to M. leprae's narrow host range and an inability to be cultured in vitro, the biological investigation of this disease has been difficult. Host genetic factors have been ...

phs000217.v1.p1 | EGA
UnknownDiscovery of a novel thiophene carboxamide analogue as a highly potent and selective sphingomyelin synthase 2 inhibitor for dry eye disease therapy.
Not available
S-EPMC11873635 | biostudies-literature
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