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MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
ProteomicsStructural mechanism of γ-carboxylation coupled to vitamin K epoxidation at membrane interface
Hemostasis and various non-hemostatic physiologies require γ-carboxylation of designated glutamates in vitamin K-dependent proteins (VKDPs), a process coupled with epoxidation of vitamin K hydroquinone (KH2) by membrane-integrated γ-carboxylase (VKGC). To understand this unique biochemistry, we dete...
ORGANISM(S): Homo sapiens (Human) 
2025-12-22 | PXD052939 | Pride
Factor ix Vitamin k epoxide Vkgc Fix Γ-carboxylation Tmg2 
ProteomicsCo-IP of fHERV-K env protein and interactors
This project seeks to identify protein-protein interactions with human endogenous retrovirus K envelope protein. A flag-tagged HERV-K env construct (fHERV-K env) was expressed in HEK293 cells. An anti-flag MAb was immobilized on magnetic protein G beads was used to capture fHERV-K env and interactor...
ORGANISM(S): Homo sapiens (Human) 
2020-07-06 | PXD019702 | Pride
Ap-ms On-bead digestion Human endogenous retrovirus Co-ip 
ProteomicsiTRAQ-based proteomic analysis reveals genome-wide protein expression patterns in allohexaploid bread wheat in adaptation to potassium deficiency and an important role of jasmonic acid
Two-week old bread wheat seedlings hydroponically grown Hoagland solution were transferred to potassium (K+)-free conditions for 8 d, their root and leaf proteome profiles were assessed using iTRAQ proteome method, and NCBInr database combined with the recently published bread wheat genome informati...
ORGANISM(S): Triticum aestivum (Wheat) 
2017-10-09 | PXD003570 | Pride
Jasmonic acid Triticum aestivum l. Itraq Potassium deficiency 
UnknownVitamin K-Dependent Carboxylation of Matrix Gla Protein Influences the Risk of Calciphylaxis.
Not available
S-EPMC5461787 | biostudies-literature
ProteomicsMolecular basis of vitamin K driven γ-carboxylation at membrane interface
The γ-carboxylation of glutamate residues enables Ca2+-mediated membrane assembly of protein complexes that support broad physiological functions including hemostasis, calcium homeostasis, immune response, and endocrine regulation. Modulating γ-carboxylation level provides prevalent treatments for h...
ORGANISM(S): Homo sapiens (Human) 
2026-01-26 | PXD059315 | Pride
Human Electron microscopy Cryo-em Post-translational modifications Lc-ms/ms 
ProteomicsLarge-scale profiling of unexpected tryptic cleaved sites at ubiquitinated lysines
Trypsin specifically cleaves the C-terminus of lysine and arginine residues and is assumed to fails to cleave ubiquitin-modified sites. Based on this perception, the irregularly-cleaved ubiquitinated peptides were often regarded as false positives and discarded in proteomic analysis. Interestingly, ...
ORGANISM(S): Homo Sapiens 
2023-01-10 | PXD039353 |
ProteomicsQuantitative Proteomics Reveals a Role for Epigenetic Reprogramming During Human Monocyte Differentiation
The data submitted is for the proteomics data published in the paper: Quantitative proteomics reveals a role for epigenetic reprogramming during human monocyte differentiation D Nicholas, H Tang, Q Zhang, J Rudra, F Xu, W Langridge, K Zhang Molecular & Cellular Proteomics 14 (1), 15-29.
ORGANISM(S): Homo sapiens (Human) 
2024-11-27 | PXD058308 | Pride
Epigenetics Macrophages Monocyte Quantitative proteomics Dendritic cells 
UnknownStudy on Yang-Xu Using Body Constitution Questionnaire and Blood Variables in Healthy Volunteers.
Not available
S-EPMC4906219 | biostudies-literature
UnknownK+-Dependent Photocycle and Photocurrent Reveal the Uptake of K+ in Light-Driven Sodium Pump.
Not available
S-EPMC10572131 | biostudies-literature
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