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MetabolomicsExogenous L-Alanine promotes phagocytosis multidrug-resistant bacterial pathogens (V. parahaemolyticus-infected spleen metabolomics)

Multidrug-resistant bacteria present a major threat to public health. Therefore, new drugs or approaches are urgently needed to manage and mitigate this threat. Here, we screen the molecular candidates that allow the survival of mice upon Vibrio parahaemolyticus infection by integrated p...

2024-09-26 | MTBLS7996 | MetaboLights
ProteomicsAKIR-1 protein-protein interactions in C. elegans
We combined transgenic AKIR-1::GFP C. elegans strain and label-free quantitative affinity purification to identify protein interaction partners of AKIR-1. An additonal pull-down experiment was performed to study AKIR-1 interactions under Drechmeria coniospora infection.
ORGANISM(S): Caenorhabditis elegans 
2018-06-19 | PXD008074 | Pride
C. elegans Akir-1 Ppi 
ProteomicsIn vivo protein-protein interaction in C. elegans early embryos
We combine in vivo expressed GFP-tagged proteins with quantitative proteomics to identify protein-protein interactions of selected key proteins involved in early C. elegans embryogenesis. Co-affinity purification of interaction partners for eight bait proteins resulted in a pilot in vivo interaction...
ORGANISM(S): Caenorhabditis elegans 
2016-02-29 | PXD002624 | Pride
C. elegans 
ProteomicsExtending the coverage of Lys-C/trypsin-based bottom-up proteomics using cysteine S-aminoethylation
In this study, S-aminoethylation of Cys (AE-Cys) was carried out with 2-bromoethylamine to form pseudo-Lys, which was then digested with Lys-C or trypsin to improve proteome coverage in bottom-up proteomics. A model study with bovine serum albumin showed that the C-terminal side of Cys was successfu...
ORGANISM(S): Homo Sapiens (human) Bos Taurus 
2023-09-27 | PXD045433 | JPOST Repository
ProteomicsProtein-protein interactions of DRSH-1 and PASH-1 in C. elegans
A mass spectrometry-based proteomics analysis was performed to study the protein binders of DRSH-1 and PASH-1 in C. elegans.
ORGANISM(S): Escherichia coli Caenorhabditis elegans 
2025-03-13 | PXD052084 | Pride
C. elegans Drsh-1 Protein-protein interactions Pash-1 
ProteomicsProtein-protein interactions of MEG-3 in C. elegans early embryos
We combined in vivo expressed GFP-tagged MEG-3 (GEI-12) with label-free quantitative proteomics to identify protein-protein interactions of MEG-3 in early C. elegans embryos.
ORGANISM(S): Caenorhabditis elegans 
2021-07-01 | PXD012852 | Pride
Ap-ms Early embryo Ppi Meg-3 C. elegans Gei-12 
UnknownMechanism of protective effect of xuan-bai-cheng-qi decoction on LPS-induced acute lung injury based on an integrated network pharmacology and RNA-sequencing approach.
Not available
S-EPMC8237774 | biostudies-literature
TranscriptomicsComparative profiling in 13 muscle disease groups
Summary: Genetic disorders of muscle cause muscular dystrophy, and are some of the most common inborn errors of metabolism. Muscle also rapidly remodels in response to training and innervation. Muscle weakness and wasting is important in such conditions as aging, critical care medicine, space flig...
ORGANISM(S): Homo sapiens 
2005-10-14 | E-GEOD-3307 | biostudies-arrayexpress
TranscriptomicsExpression data from rice plants showing hybrid weakness syndrome
Reproductive barriers perform a vital role during speciation1. Hybrid weakness, the poor development of hybrids compared to their parents, hinders gene exchange between different species at the postzygotic stage2,3. The molecular and evolutionary mechanisms of hybrid weakness are poorly understood2...
ORGANISM(S): Oryza sativa 
2014-01-22 | E-GEOD-54243 | biostudies-arrayexpress
ProteomicsFungus-host protein-protein interactions between Drechmeria coniospora and Caenorhabditis elegans
Label-free quantitative affinity purification experiments were performed to identify the host protein binders of D. coniospora fungal virulence factors in C. elegans.
ORGANISM(S): Caenorhabditis elegans 
2020-11-20 | PXD021929 | Pride
Innate immunity Ap-ms Ppi C. elegans Drechmeria coniospora Fungus-host interaction 
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