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We obtained human embryonic and fetal lungs from 5-22 pcw for scRNAseq and scATACseq analysis. To focus on epithelial differentiation and region specialization, we deeply sampled 15, 18, 20 and 22 pcw lungs and separated proximal and distal regions while leaving lungs at 5, 6, 9 and 11 pcw intact. T...
ORGANISM(S): Homo sapiens 
Using H1299 wild-type cells and their MPND-knockout derivatives as research subjects, this project employs Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) for metabolic labeling of the two cell groups. Combined with ubiquitinated peptide-specific enrichment and nano-liquid chromatogra...
ORGANISM(S): Homo sapiens (Human) 
2026-05-15 | PXD074990 | Pride
he Mpr1/Pad1 N-terminal domain-containing protein (MPND) belongs to the JAMM family of deubiquitinases and is ubiquitously expressed across human tissues. However, its role in non-small cell lung cancer (NSCLC) remains unexplored. In this study, we demonstrate that MPND expression is frequently redu...
ORGANISM(S): Homo sapiens (Human) 
2026-05-15 | PXD067575 | Pride
In this study, we hypothesized that IL-27 could induce the expression of novel miRNAs in macrophages which may have functional relevance in terms of anti-viral activity. In this study, primary monocytes were differentiated into macrophages using M-CSF (M-Mac) or with a combination of M-CSF and IL-27...
ORGANISM(S): Homo sapiens 
Fractionaion of nuclear periphery and core, followed by DDA in primary HFFs at 1 hour post infection with ICP0-RF HSV-1; IP-PRM of IFI16 in primary HFFs at 1 hpi; in vitro kinase assay with IFI16 and select kinases and quantification on phosphorlyated peptides by PRM.
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2023-05-22 | PXD034348 | Pride
Kai-Xin-San (KXS) is one of the classic famous traditional Chinese medicine prescriptions for amnesia, which has been applied for thousands of years. Modern pharmacological research has found that KXS has significant therapeutic efficacy on nervous system diseases, which is related to its antioxidan...
2023-12-21 | MTBLS8806 | MetaboLights
In the prolonged arms race between viruses and their host plants, viruses usually encode viral suppressors of RNA silencing (VSR) to overcome the hosts' defense mechanism by inhibiting RNAi. Barley stripe mosaic virus (BSMV) is an RNA virus characterized by a positive single-stranded genetic structu...
ORGANISM(S): Nicotiana Benthamiana 
2024-02-20 | PXD049705 |
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