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Introducing a clinical-practical, alternative splicing activity-based proteogenomic method that identifies, in their oncogenically active states, biomarker genes bearing patient-specific GE or copy-number alterations of prognostic significance. This integrated multi-omics method uses intronic splici...
ORGANISM(S): Homo sapiens (Human) 
2018-03-20 | PXD008642 | Pride
Investigation of whole genome gene expression level changes in Plasmodium falciparum 3D7 delta-PfPuf2 mutant, compared to the wild-type strain 3D7. The mutation engineered into this strain render tanslational control. The mutants analyzed in this study are further described in Miao J, Li J, Fan Q, ...
ORGANISM(S): Plasmodium falciparum 3D7 
CDK4/6 inhibitors (CDK4/6i) are effective in metastatic breast cancer, but they have been only modestly effective in most other tumor types. Here we show that tumors expressing low CDK6 rely on CDK4 function, and are exquisitely sensitive to CDK4/6i. In contrast, tumor cells expressing both CDK4 and...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD023137 | Pride
Drosophila Melanogaster has been extensively used as a model system to study ionizing radiation and chemical induced mutagenesis, double strand break repair and recombination. However, there are only limited studies on nucleotide excision repair in this important model organism. In this study, we im...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-04-04 | PXD028924 | Pride
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