Excessive renal fibrosis is a common pathology in progressive chronic kidney diseases. Inflammatory injury and aberrant repair processes contribute to the development of kidney fibrosis. Myeloid cells, particularly monocytes/macrophages, play a crucial role in kidney fibrosis by releasing their proi...
Renal fibrosis, a hallmark of chronic kidney diseases, is driven by the activation of renal fibroblasts. Recent studies have highlighted the role of glycolysis in this process. Nevertheless, one critical glycolytic activator, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), remain...
Immune checkpoint inhibitors (ICIs) for cancer therapy may induce immune-related adverse events including myocarditis, which occurs infrequently but carries a high mortality rate. Crocins are the active constituents derived from Crocus sativus L. (Saffron), and have demonstrated various bioactivitie...
Cas5, a transcriptional regulator of Candida albicans, has profound effects on the biosynthesis of cell wall proteins through regulating Candida albicans cell wall remodeling
Hyaline cartilage fibrosis is one of the important reasons for the poor prognosis of advanced osteoarthritis (OA), and is the main factor leading to joint stiffness and deformity. However, the mechanism of hyaline cartilage fibrosis remains largely unclear. Here we found that DDX5, one of the foundi...
Our data describes the first atlas of long-lived proteins in somatic and reproductive tissues of Drosophila during adult lifespan, and reveals a preferential ubiquitylation in the aging proteome.
In this study, applying a novel knowledge-based, multi-stage discovery and validation strategy we scaled down from 108 diabetes–associated metabolites to a diagnostic metabolite triplet (Met-T) and it could improve the diagnostic accuracy of prediabetes and diabetes screening.
Targeting the Galectin-7/TRPM2/Zn2+/DRP-1 signaling pathway in keratinocyte presents a prospective therapeutic strategy for mitigating SJS/TEN in the future.
