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MetabolomicsMyeloid PFKFB3-mediated glycolysis promotes kidney fibrosis
Excessive renal fibrosis is a common pathology in progressive chronic kidney diseases. Inflammatory injury and aberrant repair processes contribute to the development of kidney fibrosis. Myeloid cells, particularly monocytes/macrophages, play a crucial role in kidney fibrosis by releasing their proi...
2024-03-12 | MTBLS8278 | MetaboLights
MetabolomicsPFKFB3-mediated glycolysis boosts fibroblast activation and subsequent kidney fibrosis

Renal fibrosis, a hallmark of chronic kidney diseases, is driven by the activation of renal fibroblasts. Recent studies have highlighted the role of glycolysis in this process. Nevertheless, one critical glycolytic activator, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), remain...

2024-03-12 | MTBLS8281 | MetaboLights
ProteomicsAntifungal potential of naphthoquinone derivatives: Screening of shikonin-based compounds and mechanistic insights into 5,8-dihydroxy-1,4-naphthoquinone against Candida albicans in vitro and in vivo
These data present the mass spectrometry results from the proteomic profiling of PNP-02 against Candida albicans
ORGANISM(S): Candida Albicans 
2026-01-28 | PXD073742 |
ProteomicsThe effects of Cas5 on the protein biosynthesis of Candida albicans
Cas5, a transcriptional regulator of Candida albicans, has profound effects on the biosynthesis of cell wall proteins through regulating Candida albicans cell wall remodeling
ORGANISM(S): Candida Albicans 
2024-05-07 | PXD052043 |
ProteomicsDDX5 inhibits hyaline cartilage fibrosis and degradation in osteoarthritis via alternative splicing and G-quadruplex unwinding
Hyaline cartilage fibrosis is one of the important reasons for the poor prognosis of advanced osteoarthritis (OA), and is the main factor leading to joint stiffness and deformity. However, the mechanism of hyaline cartilage fibrosis remains largely unclear. Here we found that DDX5, one of the foundi...
ORGANISM(S): Mus Musculus 
2024-03-13 | PXD050571 |
ProteomicsTargeting the Galectin-7/TRPM2/Zn2+/DRP-1 Signaling Pathway: A Potential Therapeutic Intervention in the Pathogenesis of SJS/TEN
Targeting the Galectin-7/TRPM2/Zn2+/DRP-1 signaling pathway in keratinocyte presents a prospective therapeutic strategy for mitigating SJS/TEN in the future.
ORGANISM(S): Homo Sapiens 
2024-12-23 | PXD059206 |
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