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ProteomicsProximity Proteomics Revealed Dicer1 and Transporters as Client Proteins of Aha1
Co-chaperone Aha1 activates HSP90 ATPase to promote the folding of client proteins. However, the client proteins of Aha1 are largely unknown. By employing ascorbate peroxidase (APEX) based proximity labeling, we identified 32 proximity proteins of HSP90 that are modulated by genetic depletion of Aha...
ORGANISM(S): Pan troglodytes (Chimpanzee) Homo sapiens (Human) 
2022-11-19 | PXD028980 | Pride
Hsp90 Dicer1 Apex Proximity labeling Aha1 
ProteomicsThe host targets of SARS-CoV-2 protein NSP5
To identity the host targets of the SARS-CoV-2 protease NSP5, SILAC-based quantitative proteomics was performed in comparing the binding partners of wildtype or catalytically-inactive C145A mutant.
ORGANISM(S): Homo sapiens (Human) 
2021-10-27 | PXD023277 | Pride
Silac Sars-cov-2 Nsp5 Proximity labeling 
ProteomicsThe proximal proteome of 17 SARS-CoV-2 proteins links to disrupted host antiviral signaling and translation
To study SARS-CoV-2 biology, we generated an atlas of 2422 human proteins vicinal to 17 SARS-CoV-2 viral proteins using proximity proteomics.
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD023239 | Pride
Sars-cov-2 Proximity labeling Bioid 
ProteomicsGlucose dissociates DDX21 dimers to regulate mRNA splicing and promote epidermal differentiation
We discovered that glucose directly bind to DDX21, induced the conformation change of the proteins and inhibit its helicase activity. Glucose also inhibits the dimerization of DDX21, re-localize DDX21 from nucleolus to nucleoplasm and reassemble DDX21 to RNA splicing complex. DDX21 is essential for ...
ORGANISM(S): Homo sapiens (Human) 
2023-01-05 | PXD028561 | Pride
Proximity labeling Ddx21 Splicing Glucose Bioid Epidermal differentiation 
ProteomicsCOOKIE-Pro: Covalent Inhibitor Binding Kinetics Profiling on the Proteome Scale
COOKIE-Pro mass spec dataset collected from Orbitrap Lumos for spebrutinib SB2 (20231129_Speb_SB2_TMT18_ScaleUp_MS2_8ul.mzML; Ascend_VQneo_ES75500_SP2_X.mzML) and ibrutinib IB-C8-DTB (Lang_HFL_IB_COOKIE_X). Two-point COOKIE-Pro data are collected form Orbitrap Ascend, named as "Ascend_VQneo_ES75500...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000095804 | MassIVE
UnknownEpistasis analysis for estrogen metabolic and signaling pathway genes on young ischemic stroke patients.
Not available
S-EPMC3480403 | biostudies-literature
UnknownLow-Density Lipoprotein Cholesterol and Mortality in Patients With Intracerebral Hemorrhage in Taiwan.
Not available
S-EPMC8802633 | biostudies-literature
UnknownLiraglutide and Cardiovascular Outcomes in Type 2 Diabetes.
Not available
S-EPMC4985288 | biostudies-literature
UnknownChallenges of one-year longitudinal follow-up of a prospective, observational cohort study using an anonymised database: recommendations for trainee research collaboratives.
Not available
S-EPMC6909648 | biostudies-literature
UnknownImpact of postoperative acute kidney injury in patients undergoing major gastrointestinal surgery on 1-year survival and renal outcomes: a national multicentre cohort study.
Not available
S-EPMC8759520 | biostudies-literature
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