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Ribosome biogenesis is a key cellular process involving numerous protein factors, some of which are deeply conserved. This is namely the case of the bacterial endoribonuclease YbeY, whose loss is associated with ribosomal abnormalities, profound changes in gene expression, altered metabolism and dea...
ORGANISM(S): Homo sapiens (Human) 
2021-04-29 | PXD014959 | Pride
The aim was to evaluate the protein composition of human mitoribosomes in YBEY knockout cells. We compared the parental cell line HEK293T-REx with the YBEY knockout cells HEK293T-RExΔYBEY.
ORGANISM(S): Homo sapiens (Human) 
2020-03-02 | PXD015310 | Pride
YBEY is an essential biogenesis factor for mitochondrial ribosomes
In order to detect genes that are directly or indirectly affected by the inactivation of the ybeY gene the transcriptomes of the WT and ybeY bacteria grown at 22°C and 37°C were determined. The two temperatures were chosen since temperature is an important cue regulating the virulence genes. When co...
ORGANISM(S): Yersinia enterocolitica subsp. palearctica Y11 
2014-10-23 | GSE62601 | GEO
Ribosome biogenesis relies on a number of specific factors. Some of them are remarkably conserved, suggesting that they play essential roles even in distant evolutionary contexts. This is namely the case for the UPF0054 protein YBEY found in all bacteria, but also in many Eukarya. Proposed to act as...
ORGANISM(S): Homo sapiens 
2020-02-26 | GSE134960 | GEO
In order to detect genes that are directly or indirectly affected by the inactivation of the ybeY gene the transcriptomes of the WT and ybeY bacteria grown at 22°C and 37°C were determined. The two temperatures were chosen since temperature is an important cue regulating the virulence genes. When ...
ORGANISM(S): Yersinia enterocolitica subsp. palearctica Y11 
The endoribonuclease YbeY is linked to proper cellular morphology and virulence in Brucella abortus
The ybeY locus is hypothesized to produce an endoribonuclease, that is expressed during late exponential phase growth and regulate transcript titers. We used custom-made Affymetrix B. abortus strain 2308 derived GeneChips to compare the gene expression properties of wild type and isogenic ybeY mutan...
ORGANISM(S): Brucella abortus 
2018-04-18 | GSE113222 | GEO
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