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GenomicsGenomic localization of Cockayne syndrom B protein upon genotoxic stresses
Cockayne syndrome is an inherited premature aging syndrome associated with developmental and neurological disorders. Mutations in the genomic locus encoding CSB are associated with 80% Cockayne syndrome cases. CSB is invovled in relieving UV-induced and oxidative stree. To gain more insights into ...
ORGANISM(S): Homo sapiens 
2015-11-09 | E-GEOD-50925 | biostudies-arrayexpress
GenomicsGenome binding profile of TFIIH helicases XPB and XPD in HT1080 cells
The conserved TFIIH helicases XPB and XPD play key roles in transcription initiation and DNA repair. To investigate the functions of these helicases on a genome-wide scale, we performed ChIP-seq of endogenous XPB and XPD in the HT1080 human fibrosarcoma cell line. 2 ChIP samples and 1 unenriched inp...
ORGANISM(S): Homo sapiens 
2014-02-18 | E-GEOD-44849 | biostudies-arrayexpress
ProteomicsProtein ubiquitination in Aspergillus nidulans
Protein ubiquitination, an evolutionarily conserved post-translational modification process in eukaryotes, and plays an important role in many biological processes. Aspergillus nidulans, a model filamentous fungus, contributes to our understanding of cellular physiology, metabolism and genetics, but...
ORGANISM(S): Aspergillus 
2015-09-10 | PXD002299 | Pride
Lc-msms Aspergillus nidulans Ubiquitination Mycelial dvelopment 
ProteomicsUrinary Proteomic Characteristics of Hyperuricemia and Their Possible Links with the Occurrence of Hyperlipidemia and Type 2 Diabetes Mellitus
We performed label-free liquid chromatography MS/MS spectrometry analysis of urine samples from 26 HUA patients and 25 healthy controls, attempting to establish the possible protein links between hyperuricemia and these diseases by profiling urine proteome.
ORGANISM(S): Homo Sapiens 
2019-12-24 | PXD016900 |
ProteomicsAnalyzing downstream targets of Beauveria bassiana gelsolin duing conidal development
Comparative proteomics, between the wild type and delta BbGel1 strains grown on the surface of culture media, is performed to explore the downstream targets of Beauveria bassiana gelsolin during conidiation .
ORGANISM(S): Beauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus) (Tritirachium shiotae) 
2016-09-26 | PXD003618 | Pride
Beauveria bassiana Conidia Gelsolin 
ProteomicsDownstream targets of Beauveria bassiana gelsolin during blastospore development
Comparative proteomics, between the wild type and delta BbGel1 mutant strains grown in liquid media, is performed to explore the downstream targets of Beauveria bassiana gelsolin during balstospore development .
ORGANISM(S): Beauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus) (Tritirachium shiotae) 
2016-09-26 | PXD003617 | Pride
Beauveria bassiana Gelsolin Blastospore 
UnknownKLHL3-dependent WNK4 degradation affected by potassium through the neddylation and autophagy pathway.
Not available
S-EPMC10362690 | biostudies-literature
ProteomicsMass spectrometry-based quantification of the cellular response to ultraviolet radiation in HeLa cells
To better understand the cellular response to this form of DNA damage, we used highly sensitive mass spectrometry to perform comparative proteomics of phosphorylation in HeLa cells. A total of 4367 phosphorylation sites in 2100 proteins were identified, many of which had not been reported previously...
ORGANISM(S): Homo sapiens (Human) 
2018-04-05 | PXD006518 | Pride
Dna damage Phosphorylation Stable isotope labeling with amino acids 
TranscriptomicsKras is required for pancreatic tumor maintenance through regulation of hexosamine biosynthesis and the non-oxidative pentose phosphate pathway
The maintenance of advanced malignancies relies on continued activity of driver oncogenes, although their rate-limiting role is highly context-dependent with respect to tumor types and associated genetic alterations. Oncogenic Kras mutation is the signature event in human pancreatic ductal adenocar...
ORGANISM(S): Mus musculus 
2012-04-29 | E-GEOD-32277 | biostudies-arrayexpress
TranscriptomicsExpression profiling of host genes modulated by Epstein-Barr virus Rta in nasopharyngeal carcinoma cells
EBV Rta is a transcriptional activator that functions to disrupt EBV latency in cells of epithelial origin. This series of experiment is to identify host genes that are moduated by the expression of doxycycline-inducible EBV Rta in nasopharyngeal carcinoma cells. Designations for the two EBV Rta ind...
ORGANISM(S): Homo sapiens 
2011-05-22 | E-GEOD-24586 | biostudies-arrayexpress
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