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ProteomicsProteomics and phosphoproteomics of sepsis induced acute and chronic kidney disease
Sepsis induced acute kidney injury (AKI) is associated with a rapid decline of kidney function, leading to unacceptably high morbidity and mortality rate as well as progression to chronic kidney disease (CKD). We have recently developed a septic AKI mouse model. By quantitatively assessing the kidne...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-25 | PXD017045 | Pride
Proteomics  phosphoproteomics  sepsis  kidney  aki  ckd 
ProteomicsQuick 96FASP for high throughput quantitative proteome analysis
An upgraded and quick 96FASP approach using 30k MWCO filter plates was developed for high throughput quantitative proteomics analysis.
ORGANISM(S): Homo sapiens (Human) Klebsiella pneumoniae UHKPC27 
2018-05-24 | PXD006137 | Pride
Proteomics Fasp Quantitative proteomics 96fap 
ProteomicsActinobaculum massiliense proteome profiled in polymicrobial urethral catheter biofilms
Actinotignum massiliense, a Gram-positive, facultatively anaerobic coccoid rod, is a rare human pathogen able to infect the urinary tract and belongs to the order of Actinomycetales. We identified A. massiliense as a resident of microbial biofilms growing on indwelling urethral catheter surfaces tha...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD011327 | Pride
Uti Proteome Urethral catheter Biofilm Actinobaculum massiliense 
ProteomicsPredictive signatures of 19 antibiotics-induced Escherichia coli proteomes
Identifying the mode of action (MOA) of antibacterial compounds is the fundamental basis for the development of new antibiotics, and the challenge increases with the emerging secondary and indirect effect from antibiotic stress. Although various omics-based system biology approaches of defining anti...
ORGANISM(S): Escherichia coli 
2020-07-23 | PXD016074 | Pride
Quantitative proteomics  label-free  suspension trapping (s-trap)  escherichia coli  antibiotics  mode of action (moa). 
ProteomicsPredictive signatures of 19 antibiotics-induced Escherichia coli proteomes
Identifying the mode of action (MOA) of antibacterial compounds is the fundamental basis for the development of new antibiotics, and the challenge increases with the emerging secondary and indirect effect from antibiotic stress. Although various omics-based system biology approaches of defining anti...
ORGANISM(S): Escherichia coli 
2020-07-23 | PXD016001 | Pride
Quantitative proteomics  label-free  suspension trapping (s-trap)  escherichia coli  antibiotics  mode of action (moa) 
ProteomicsInfluenza virus infection leads to global cardiac proteome remodeling during convalescence
Influenza virus infection leads to global cardiac proteome remodeling during convalescence MTD project_description "Influenza virus infections lead to more than 500,000 hospitalizations in the U.S. every year. Patients with cardiovascular diseases have been shown to be at high risk of influenza medi...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-01 | PXD015992 | Pride
Influenza virus  proteome  remodeling  convalescence  heart 
ProteomicsDiagnosing inflammation and infection in the urinary system via proteomics
Current methodology for the diagnosis of diseases in the urinary system includes patient symptomology, urine analysis and urine culture. Asymptomatic bacteriuria from urethral colonization or indwelling catheters, sample contamination from perineal or vaginal sources, and non-infectious inflammatory...
ORGANISM(S): Homo sapiens (Human) 
2019-03-28 | PXD012414 | Pride
Urinary tract infection Neutrophil infiltration Metaproteomics Klebsiella Urine diagnostics Inflammation Gardnerella Innate immune response Proteomics Uropathogen 
ProteomicsCharacterization of Early-Phase Neutrophil Extracellular Traps in Urinary Tract Infections
Neutrophils have an important role in rapid antimicrobial defenses against and resolution of urinary tract infections (UTIs). We show that a mechanism known as neutrophil extracellular trap (NET) formation is a strategy to combat pathogens in the urinary tract. Viscous aggregates that were present i...
ORGANISM(S): Homo sapiens (Human) 
2017-01-23 | PXD005688 | Pride
Urine Neutrophil extracellular traps (nets) Urinary tract infection (uti) Proteomics Lcmsms 
ProteomicsS-Trap is an ultrafast sample preparation approach for shotgun proteomics
The success of shotgun proteomic analysis depends largely on how samples are prepared. Current approaches such as gel-, solution- or filter-based, although being extensively employed in the field, are time-consuming and less effective with respect to the repetitive sample processing, recovery, and o...
ORGANISM(S): Escherichia coli 
2019-03-28 | PXD010237 | Pride
Proteomics  sample preparation  fasp  suspension trapping  klebsiella pneumoniae  sputum  tuberculosis. 
ProteomicsAn ultrafast, reliable and economical approach for quantitative salivary proteomic profiling and oral cancer biomarker discovery
Clinical biomarkers identified by shotgun proteomics require proteins in body fluids or tissues to be enzymatically digested before being separated and sequenced by Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS). How well peptide signals can be resolved and detected is largely dependent o...
ORGANISM(S): Homo sapiens (Human) 
2019-03-12 | PXD012436 | Pride
Strap Saliva Suspension trapping Hela Clinical proteomics Oral squamous cell carcinoma Fasp Biomarker Oscc 
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