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ORGANISM(S): Danio rerio 

Circadian rhythms are essential biological oscillators that synchronize physiological processes, cellular homeostasis, and systemic metabolism with the Earth's natural 24-hour light-dark cycle. While circadian rhythm disruption (CRD) is highly prevalent in modern society due to factors such as sh...

2026-06-23 | MTBLS14815 | MetaboLights
To understand the effects of Hsp60 deficiency in developing vertebrates, we generated CRISPR/Cas9-mediated hspd1 knockout zebrafish lines by targeting exon 2 to induce a frameshift mutation. We selected an allele with a 56 base pair deletion inducing a frameshift mutation leading to loss of protein ...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2024-09-27 | PXD048920 | Pride
Purpose: This study aimed to identify differentially expressed genes and transcripts in zebrafish embryos and larvae following benzo[a]pyrene (BaP) exposure. Methods: Adult zebrafish (2 males × 4 females, N=6 replicate tanks for each treatment) were acclimated for 7 days in an 818 Low Temp Illuminat...
ORGANISM(S): Danio rerio 
In this work we investigated how the brain proteome of the larval zebrafish is modified by behavioral adaptation to the environmental challenge of a water vortex. We monitored the behavior of larvae and observed that they behaviorally adapted to the presence of a water vortex. We obtained the larval...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2019-05-24 | PXD011981 | Pride
Background: Acrylamide (ACR) is a broadly spread neurotoxic chemical of public health concern, as occupational or environmental exposure of humans to ACR may lead to a synaptopathy characterized by ataxia, skeletal muscles weakness and numbness of the extremities. Currently, only the mildly affected...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2018-10-24 | PXD007169 | Pride
Despite the involvement of several serine hydrolases (SHs) in the metabolism of xenobiotics such as dibutyl phthalate (DBP), no study has focused on mapping this enzyme class in zebrafish, a model organism frequently used in ecotoxicology. Here, we survey and identify active SHs in zebrafish larvae ...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2023-03-11 | PXD038229 | Pride
Transcriptome analysis of the heads of 6 dpf sv2a-/-, sv2a+/- and sv2a+/+ zebrafish larvae to provide insights into the neuropathological processes underlying the observed epileptic phenotype in sv2a-/- zebrafish larvae.
ORGANISM(S): Danio rerio 
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