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MetabolomicsBile acid is a significant host factor shaping the gut microbiome of diet induced obese mice (untargeted metabolome profile assay)

BACKGROUND: Intestinal bacteria are known to regulate the bile acid (BA) homeostasis via intestinal biotransformation of BAs and stimulating the expression of fibroblast growth factor 19 through intestinal nuclear farnesoid X receptor (FXR). On the other hand, BAs directly regula...

2017-11-23 | MTBLS545 | MetaboLights
MetabolomicsBile acid is a significant host factor shaping the gut microbiome of diet induced obese mice (targeted bile acid analysis assay)

BACKGROUND: Intestinal bacteria are known to regulate the bile acid (BA) homeostasis via intestinal biotransformation of BAs and stimulating the expression of fibroblast growth factor 19 through intestinal nuclear farnesoid X receptor (FXR). On the other hand, BAs directly regula...

2017-11-23 | MTBLS547 | MetaboLights
MetabolomicsBile acid is a significant host factor shaping the gut microbiome of diet induced obese mice (targeted free fatty acid analysis assay)

BACKGROUND: Intestinal bacteria are known to regulate the bile acid (BA) homeostasis via intestinal biotransformation of BAs and stimulating the expression of fibroblast growth factor 19 through intestinal nuclear farnesoid X receptor (FXR). On the other hand, BAs directly regula...

2017-11-23 | MTBLS548 | MetaboLights
MetabolomicsBile acid is a significant host factor shaping the gut microbiome of diet induced obese mice (targeted short chain fatty acid analysis assay)

BACKGROUND: Intestinal bacteria are known to regulate the bile acid (BA) homeostasis via intestinal biotransformation of BAs and stimulating the expression of fibroblast growth factor 19 through intestinal nuclear farnesoid X receptor (FXR). On the other hand, BAs directly regula...

2017-11-23 | MTBLS546 | MetaboLights
MetabolomicsAnti-anemia drug FG4592 retards the AKI to CKD transition by improving vascular regeneration and anti-oxidative capability (day 21)

Acute kidney injury (AKI) is a known risk factor for the development of chronic kidney disease (CKD), with no satisfactory strategy to prevent the progression of AKI to CKD. Damage to the renal vascular system and subsequent hypoxia are common contributors to both AKI and CKD. Hypoxia inducible f...

2021-07-22 | MTBLS3003 | MetaboLights
MetabolomicsAnti-anemia drug FG4592 retards the AKI to CKD transition by improving vascular regeneration and anti-oxidative capability (day 10)

Acute kidney injury (AKI) is a known risk factor for the development of chronic kidney disease (CKD), with no satisfactory strategy to prevent the progression of AKI to CKD. Damage to the renal vascular system and subsequent hypoxia are common contributors to both AKI and CKD. Hypoxia inducible f...

2021-07-22 | MTBLS3056 | MetaboLights
ProteomicsIntegrated proteomic and transcriptomic analyses reveal the roles of Brucella BI-1 in cell division and membrane homeostasis of Brucella suis S2
To explore the role of Brucella BI-1 in Brucella suis S2, we constructed the Brucella BI-1 deletion mutant strain and its complementary strain. We then determined the effect of Brucella BI-1 deletion on the physiological characteristics of Brucella suis S2 and revealed them via integrated transcript...
ORGANISM(S): Brucella Suis Bv. 1 Str. S2 
2020-11-13 | PXD022537 |
ProteomicsUbiquitylation-omics analysis on WWP2 overexpressed mouse tubular epithelial cells (MPTCs)
WWP2 is a E3 ubiquitin ligase which may be implicated in multiple cellular event. WWP2 expressed in the kidneys and its pathological role remain to be elucidated. We performed this ubiquitylation omics analysis on renal tubular epithelial cells which overexpressd WWP2 to study WWP2's potential ubiqu...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-09 | PXD048540 | Pride
Renal tubular epithelial cells Ubiquitylation-omics 
ProteomicsQuantitative proteinomics on WWP2 overexpressed human tubular epithelial cells HK-2
WWP2 is a E3 ligase which regulates multiple cellular events, such as stress response, differentiation. WWP2 played physiological role in the distal tubules of the kidneys. Whether WWP2 regulated pathophysiological rol in the proximal tubules is unclear. In the present study, we stably overexpressed...
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD048622 | Pride
Human tubular epithelial cells Wwp2 Proteinomics 
UnknownA Comparative Analysis of the Anti-Tumor Activity of Sixteen Polysaccharide Fractions from Three Large Brown Seaweed, Sargassum horneri, Scytosiphon lomentaria, and Undaria pinnatifida.
Not available
S-EPMC11278018 | biostudies-literature
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