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MetabolomicsDeciphering the metabolic perturbation in hepatic alveolar echinococcosis: a 1H NMR-based metabolomics study

BACKGROUND: Hepatic alveolar echinococcosis (HAE) is caused by the growth of Echinococcus multilocularis larvae in the liver. It is a chronic and potentially lethal parasitic disease. Early stage diagnosis for this disease is currently not available due to its long asymptomatic ...

2021-08-03 | MTBLS981 | MetaboLights
ProteomicsA549 overexpressing CCAR1 LC-MS/MS
CCAR1 mRNA have two transcripts, the 3.5 kb full length transcript and the 2.5 kb shorter transcript which contained a deletion in exon 15—exon 22 of full-length CCAR1 cDNA, where sequences mapped to 1196–3120 bp were missed. CCAR1L and CCAR1S shared a common N-terminus and a common C-terminal end, ...
ORGANISM(S): Homo sapiens (Human) 
2018-05-15 | PXD009266 | Pride
Ip-ms A549 Ccar1 
ProteomicsSystematic discovery of linear ubiquitination mediated neo-protein-protein interactions across mouse tissues
HOIP truncations proteins GST-PUB, GST-NZF, GST-UBA and GST-RBR-LDD were purified, GST was used as a negative control. The tissue lysates from the C57BL/6 mice were incubated with glutathione-S-transferase (GST) beads which bound to the GST-HOIP truncation proteins beforehand. The pull-down componen...
ORGANISM(S): Mus Musculus 
2024-02-28 | PXD043322 |
ProteomicsCaspase-2 is a condensate-mediated deubiquitinase in protein quality control
When cells encounter proteome stresses, caspase-2 accumulates in a ubiquitin-rich condensate, which functions as a deubiquitinase to cleave the overloaded ubiquitinated proteins.
ORGANISM(S): Homo Sapiens 
2023-09-06 | PXD041964 |
ProteomicsProtein differential profiling of OTUB1 knockout osteoblasts
This project is to figure out the differential proteins in control and OTUB1 knockout osteoblast cells
ORGANISM(S): Mus Musculus 
2023-01-17 | PXD039507 |
ProteomicsO-SaMPle: an optimized workflow for human salivary metaproteomic analysis reveals taxonomic and functional dysbiosis in IBD patients
We developed an Optimized Salivary MetaProteomic sample analysis workflow (O-SaMPle) to enrich salivary bacteria and reduce host-derived interferences for in-depth analysis of the oral metaproteome. This workflow integrates using selective microbial enrichment buffer and differential centrifugation...
ORGANISM(S): Human Oral Bacteria Ensemble 
2024-08-26 | PXD055269 |
ProteomicsDRUSP_A novel method of super-enhanced purification of ubiquitinome
A novel approach that combines Denatured-Refolded Ubiquitinated Sample Preparation (DRUSP) with a tandem hybrid specific UBD (ThUBD) for ubiquitinomic analysis.
ORGANISM(S): Mus Musculus 
2024-08-28 | PXD055428 |
ProteomicsProximity labeling proteins differences between TRIM25 and G3BP1 interactions or not, and Proximity labeling proteins differences between G3BP1 and TRIM25 in the presence or absence of poly(I:C) stimulation
This project investigates G3BP1 proximity proteins by constructing a G3BP1-BirA* fusion protein using G3BP1 as a decoy protein and BirA* as a biotin ligase. The changes in G3BP1 proximity proteins were studied in the presence or absence of poly(I:C) stimulation conditions, using poly(I:C) stimulatio...
ORGANISM(S): Homo Sapiens 
2023-07-07 | PXD043603 |
ProteomicsProteomics and phosphoproteomics reveal dysregulated kinases and associated pathway in liver fibrosis
Liver fibrosis is the initial stage of most liver diseases, and it is also a pathological process involving the liver in the late stages of many metabolic diseases. Therefore, it is important to systematically understand the pathological mechanism of liver fibrosis and seek therapeutic approaches fo...
ORGANISM(S): Mus Musculus 
2025-01-16 | PXD059906 |
ProteomicsProteomic analysis of Hypsibius henanensis sp.nov. suffered from 12C6+ heavy ion radiation based on label-free technology
Tardigrades are a kind of species that can tolerate ultra-high doses of ionizing radiation. Here, we used heavy ions at different doses of 0,200 and 2000Gy to irradiate Hypsibius henanensis sp.nov.. Label-free proteomic identification was performed on the samples, each dose containing 3 repetitions
ORGANISM(S): Tardigrada 
2023-09-20 | PXD045537 |
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