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MetabolomicsCharacterization of white tea metabolome: comparison against green and black tea by a nontargeted metabolomics approach
White tea is considered the least processed form of tea and is reported to have a series of potent bioactivities, such as antioxidant, anti-inflammatory, anti-mutagenic, and anti-cancer activities. However, the chemical composition of white tea and the dynamic changes of the metabolites during the m...
2017-03-23 | MTBLS403 | MetaboLights
ProteomicsIn-cell isotope-coded labeling and LC-MS/MS analysis probe warfarin inhibition mechanism
Warfarin targets human vitamin K epoxide reductase (hVKOR), a redox enzyme in the membrane of endoplasmic reticulum (ER), to prevent the formation of blood clots. Although warfarin has been a popular medication since 1954, its mechanism of action is still unclear. A fundamental issue is the controve...
ORGANISM(S): Homo sapiens (Human) 
2017-03-30 | PXD003774 | Pride
Human vitamin k epoxide reuctase N-ethylmeleimide Isotope Bottom-up proteomics Warfarin 
ProteomicsProteomic Analysis of adipose tissue derived Exosome-like vesicles
Scope: Adipose tissue is regarded as a true endocrine organ. Recent studies showed that adipose tissue derived exosomes could serve as carrier of circulating miRNAs to regulate distant targets. However, the characteristics of exosomal proteins released from adipose tissue have not been investigated ...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-07-02 | PXD013270 | Pride
Exosome-like vesicles Obesity Adipokines Adipose tissue 
ProteomicsPlasma proteomics characteristics of subclinical vitamin E deficiency of dairy cows during early lactation
A total of 80 cows were selected from 0 to 30 days after parturition, and α-tocopherol concentration in plasma of 80 cows was detected. According to the concentration of α-tocopherol in plasma, subclinical VE deficiency group (2-3 μg/mL α-tocopherol) and healthy control group (>4 μg/mL α-tocopherol)...
ORGANISM(S): Bos Taurus 
PXD026856 |
ProteomicsProteomic studies of mechanism of action of apigenin in stromal cells by five proteomic experiments
The present studies consist of five proteomic experiments: proteomic profiling treated by apigenin; DARTS coupled MS analysis to identify the potential directed proteins targets of apigenin; Identification of the potential directed protein targets of biotin-apigenin by pull-down coupled MS analysis;...
ORGANISM(S): Homo Sapiens 
2025-01-20 | PXD055761 |
ProteomicsProteins raw data using CT-1 in MDA-MB-231
The MDA-MB-231 cells were treated with CT-1 for 24 h. Then the cells were collected for proteomic analysis. SDT buffer was used for sample lysis and protein extraction. Protein digestion by trypsin was performed according to filter-aided sample preparation (FASP) procedure described by Matthias Mann...
ORGANISM(S): Homo Sapiens 
2024-10-30 | PXD057337 |
ProteomicsMesenchymal stem cell derived exosomal microRNA-34c-5p ameliorates renal pericyte activation by inhibiting core fucosylation
Renal interstitial fibrosis(RIF) is an incurable pathological lesion in progressive chronic kidney diseases. Myofibroblasts proliferation and microvascular damage are two important events of RIF and pericyte is one of the major sources of myofibroblasts in kidney. However, the underlying mechanisms ...
ORGANISM(S): Mus Musculus 
2020-11-04 | PXD022358 |
ProteomicsTo explore the binding protein of HKDC1 by IP-MS
We used Hep3B cells expressing Flag tagged HKDC1 to explore the binding protein of HKDC1 by IP-MS
ORGANISM(S): Homo Sapiens 
2023-11-29 | PXD047388 |
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