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MetabolomicsMirabegron displays anticancer effects by globally browning adipose tissues

Metabolic reprogramming in malignant cells is a hallmark of cancer that relies on augmented glycolytic metabolism to support their growth, invasion and metastasis. However, the impact of global adipose metabolism on tumor growth and the drug development by targeting adipose metabolism remain larg...

2023-11-08 | MTBLS8682 | MetaboLights
ProteomicsHPLC-MS datasets of LINP1 RNA pulldown samples in A431 cells
We performed LINP1 RNA pulldown followed by HPLC-MS analysis to identify LINP1-interacting proteins in A431 cells. With high performance liquid chromatography-mass spectrometry (HPLC-MS), the binding protein of LINP1 from RNA pull down was detected by removing non-specific protein which were binding...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD032027 | Pride
Human a431 cells hplc-ms 
ProteomicsProteome of extracellular vesicles derived from breast cancer cells
MDA-MB-231 cells were irradiated with 10 Gy X-rays and the medium was harvest for extracellular vesicles isolation 24 hours post-irradiation. Proteins carrying by EVs of irradiated and control cells were then analysed by LC-MS.
ORGANISM(S): Homo Sapiens 
2024-04-22 | PXD051650 |
ProteomicsAffinity purification of TRMT6/61A protein complexes
In order to identify the molecular mechanism leading to the increase of TRMT6/61A complex in aged HSCs, we purified proteins interacting with TRMT6 and TRMT61A via affinity purification. HEK293T cells stably expressing SFB-tagged TRMT6 or SFB-TRMT61A were lysed in NETN buffer (20 mM Tris-HCl [pH 8.0...
ORGANISM(S): Homo Sapiens 
2023-11-30 | PXD047430 |
ProteomicsMass spectrometry for the proteomics following RNA pull down of m6A methylated RN7SK in lung adenocarcinoma A549 cell line.
The aim of this project was to investigate the proteins that bind to m6A methylated RN7SK in lung adenocarcinoma A549 cell line. And mass spectrometry of A549 cell treated with or without m6A methylated RN7SK in three replicates.
ORGANISM(S): Homo Sapiens 
2022-04-12 | PXD033184 |
ProteomicsHEK cells expressing miRFP680-P2A-GFP, emiRFP670-P2A-GFP, emiRFP703-P2A-GFP, miRFP713-P2A-GFP and miRFP720-P2A-GFP
HEK cells transiently transfected with pAAV-CAG-NIR-FPs-P2A-GFP plasmids were processed using Mini MS Sample Prep kit according to the manufacture protocol. Extracted peptides were analyzed using Orbitrap Fusion Lumos mass spectrometer (Thermo Fisher) in data-independent acquisition (DIA) mode. We ...
ORGANISM(S): Homo Sapiens 
2023-06-07 | PXD042781 |
ProteomicsSpatially Resolved Proteomics via Tissue Expansion
Spatially resolved proteomics is an emerging approach, however, it remains technically challenging due to the complexity of the tissue microsampling techniques and mass spectrometry analysis of nanoscale specimen volumes. Here, we describe an expansion proteomics method ProteomEx, a combination of t...
ORGANISM(S): Mus <genus> 
2022-11-04 | PXD037950 |
Proteomicsproteomics of m6A-High and m6A-Low LUAD tissues
The dataset includes the sequencing data of m6A-high and m6A-low LUAD tissues, each of which contains five biological replicates. A total of 3437 protein groups were obtained, 407 differential proteins were obtained . Exerllent repeatability for different biological replicates is indicated based on...
ORGANISM(S): Homo Sapiens 
2021-07-29 | PXD027633 |
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