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MetabolomicsSupplementation of Bacillus sp. DU-106 reduces hypercholesterolemia and ameliorates gut dysbiosis in high-fat diet rats

Gut microbiota modulation by a probiotic is a novel therapy for hypercholesterolemia mitigation. This study initially investigated the potential hypocholesterolemic effect of Bacillus sp. DU-106 in hypercholesterolemic rats and explored its potential relation with gut microbiota. Sprague-Dawley r...

2021-04-08 | MTBLS1168 | MetaboLights
ProteomicsIdentification of DDR1-interacting proteins by IP-MS screening
To investigate and identify the potential DUBs that stabilize and interact with DDR1, we performed immunoprecipitation of endogenous DDR1 with anti-DDR1 antibody (specific IP) or anti-IgG antibody (negative control) in A549 cells followed by mass spectrometry analysis.
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD065332 | Pride
Ddr1 Ip-ms Co-immunoprecipitated proteins 
ProteomicsNanoliposuction recycles senescent cell lipids for lubrication
This study aims to systematically profile membrane protein alterations associated with chondrocyte senescence, in order to identify surface markers specifically upregulated in aged cartilage. We established two in vitro models by treating primary chondrocytes with IL-1β or bleomycin, and one in vivo...
ORGANISM(S): Mus Musculus 
PXD064867 |
ProteomicsProtein response of lncRNA-DRC to HU treatment
protein response of lncRNA-DRC overexpression (mec1Δ sml1Δ-lncRNA-DRC-OE) to HU treatment
ORGANISM(S): Saccharomyces Cerevisiae 
PXD056715 |
ProteomicsThe antibacterial mechanism of sertindole against Staphylococcus aureus
Clinically isolated MRSA strain was inoculated and cultured to exponential growth phase (OD600 at 0.5) in TSB and divided into two groups, the control group and the drug treated group. Sertindole was added to the drug treated group until a final concentration of 1/2× MIC reached, and DMSO added as L...
ORGANISM(S): Staphylococcus Aureus 
PXD035364 |
ProteomicsA Multi-omics Comparison Unveils Convergent and Divergent Antidepressant Mechanisms of Fluoxetine and St. John's Wort extract
A Multi-omics Comparison Unveils Convergent and Divergent Antidepressant Mechanisms of Fluoxetine and St. John's Wort extract
ORGANISM(S): Mus Musculus 
PXD067684 |
ProteomicsComparative secretome analysis of Magnaporthe oryzae identified N-glycosylation proteins involved in fungal pathogenicity and cell wall integrity
Plant fungal pathogens secrete numerous proteins into the apoplast at the plant-fungus contact sites to facilitate colonization. Only a limited number of secreted proteins have been functionally characterized in Magnaporthe oryzae, the causal agent of blast disease in rice (Oryza sativa). Intriguing...
ORGANISM(S): Magnaporthe Oryzae P131 
2021-03-12 | PXD024706 |
ProteomicsHSPA1A and DNAJB1 regulate NELF condensate reversibility to safeguard transcriptional recovery under heat stress
The negative elongation factor (NELF) is essential in establishing RNA Polymerase II (Pol II) pausing at promoter-proximal regions, providing a key regulatory checkpoint for precise gene expression control. In response to heat shock (HS) stress, NELF has been observed to form nuclear condensates, bu...
ORGANISM(S): Homo Sapiens 
PXD064175 |
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