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TranscriptomicsGenome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells
Recent studies have demonstrated that the Ten-eleven translocation (Tet) family proteins can enzymatically convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). While 5mC has been studied extensively, little is known about the distribution and function of 5hmC. Here we present a genome...
ORGANISM(S): Mus musculus 
2011-03-30 | E-GEOD-27613 | biostudies-arrayexpress
GenomicsDual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells (ChIP-Seq)
Epigenetic modification of the mammalian genome by DNA methylation (5-methylcytosine) has a profound impact on chromatin structure, gene expression and maintenance of cellular identity. Recent demonstration that members of the Ten-eleven translocation (Tet) family proteins can convert 5-methylcytosi...
ORGANISM(S): Mus musculus 
2011-03-30 | E-GEOD-26832 | biostudies-arrayexpress
ProteomicsIn-vitro culture of single gut bacterial strains with added sugars
Gut commensal bacterial strains were cultured with or without added sugars (glucose, sucrose and kestose). The base culture medium without sugar added were modified based on the Yeast Casitone Fatty Acids (YCFA) broth. Samples were analyzed for proteomics using LC-MS/MS.
ORGANISM(S): Blautia hydrogenotrophica DSM 10507 Bacteroides thetaiotaomicron Escherichia coli Phocaeicola vulgatus ATCC 8482 Bacteroides uniformis ATCC 8492 Bacteroides ovatus ATCC 8483 
2023-06-08 | PXD037923 | Pride
Proteomics Single strains Culturing 
TranscriptomicsDual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells (mRNA)
Epigenetic modification of the mammalian genome by DNA methylation (5-methylcytosine) has a profound impact on chromatin structure, gene expression and maintenance of cellular identity. Recent demonstration that members of the Ten-eleven translocation (Tet) family proteins can convert 5-methylcytosi...
ORGANISM(S): Mus musculus 
2011-03-30 | E-GEOD-26830 | biostudies-arrayexpress
TranscriptomicsDual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells (ChIP-chip and MeDIP-chip)
Epigenetic modification of the mammalian genome by DNA methylation (5-methylcytosine) has a profound impact on chromatin structure, gene expression and maintenance of cellular identity. Recent demonstration that members of the Ten-eleven translocation (Tet) family proteins can convert 5-methylcytosi...
ORGANISM(S): Mus musculus 
2011-03-30 | E-GEOD-26827 | biostudies-arrayexpress
ProteomicsM.musculus - Suprachiasmatic nucleus, iBAQ (Chiangetal,plosgenetics.2014)
abundance based on iBAQ, Interaction consistency score: 15.5, Coverage: 18
ORGANISM(S): 10090 
2014-00-00 | 1300563876 | PAXDB
GenomicsDynamically reorganized chromatin is the key for the reprogramming of somatic cells to pluripotent cells
We investigated genome-wide nucleosome coverage and histone methylation occupancies in somatic MEFs, intermediate pre-iPSCs and fully reprogrammed iPSCs. We found that nucleosome occupancies increased in promoter regions and decreased in intergenic regions in pre-iPSCs and then recover to an interme...
ORGANISM(S): Mus musculus 
2015-12-13 | E-GEOD-60627 | biostudies-arrayexpress
ProteomicsIntegrated Transcriptomic and Proteomic Analysis to Identify Genes and Molecular Mechanisms Regulating Deer Antler Growth and Ossification
Velvet antler is an organ composed of skin, nerves, blood vessels, cartilage and other tissues. Due to its ability to regenerate annually, it is used as a model for regeneration and medical research into cartilage related diseases. The study of the growth and development mechanisms of antlers has be...
ORGANISM(S): Elaphurus Davidianus 
2024-09-18 | PXD056140 |
ProteomicsGlobal quantification of glutathione S-transferases in human serum using LC-MS/MS coupled with affinity enrichment
The concentrations of glutathione S-transferases (GSTs) in serum are considered disease biomarkers. Members of the GST superfamily often exhibit functional overlap, and can compensate for each other. Global and quantitative evaluation of serum GSTs is therefore urgent, but we currently lack an effic...
ORGANISM(S): Homo Sapiens 
2022-01-19 | PXD031061 |
ProteomicsIdentification of ANXA1 as A Novel Upstream Negative Regulator of Notch1 Function in AML
Abnormal Notch1 expression has an important role in tumorigenesis. However, upstream control mechanisms for Notch1 are still insufficiently understood. Acute myeloid leukemia (AML) is one of the most common and lethal blood malignancies with limited possibilities for treatment. Thus, new therapeutic...
ORGANISM(S): Homo Sapiens 
2024-10-03 | PXD056593 |
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