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MetabolomicsMetabolomic and transcriptomic investigations reveal the responses of cucumber leaves exposed to polystyrene nanoplastics (PSNPs)

The uptake and accumulation of nanoplastics by plants have raised particular concerns. However, molecular mechanisms underlying nanoplastic phytotoxicity are still vague and insufficient. Thus, its potential environmental risks and biosafety are receiving increased attention. In this study, cucum...

2024-09-27 | MTBLS3923 | MetaboLights
ProteomicsProteomic analysis of PDCoV-infected HIEC-6 cells
Data-independent acquisition (DIA) is a new type of mass spectrometry data acquisition developed in recent years. The entire scanning range of mass spectrometry can be divided into several windows based on the mass-to-charge ratio (m/z), and then all the parent ions in each window are fragmented and...
ORGANISM(S): Homo Sapiens 
2024-02-20 | PXD049713 |
ProteomicsGenome-wide identification and proteomic analysis of the wheat ABCG family reveals a pivotal role of TaABCG7B-8 in fertility conversion of a photoperiod-temperature sensitive genic male sterility wheat
Photoperiod- and temperature-sensitive genic male sterility (PTGMS) plays a central role in two-line hybrid wheat breeding, yet its underlying molecular mechanisms remain incompletely understood. In this study, we performed a genome-wide identification of the ATP-binding cassette subfamily G (ABCG) ...
ORGANISM(S): Triticum Aestivum 
2026-01-04 | PXD072615 |
ProteomicsMulti-Omics Analysis Reveals Alcohol exposure affects Ferroptosis pathway in Brain
Alcohol-related brain damage (ARBD) constitutes a major global public health issue and is often comorbid with neuropsychiatric disorders such as Alzheimer's and Parkinson's diseases. Ferroptosis, a form of regulated cell death characterized by iron dependency and lipid peroxidation, has been implica...
ORGANISM(S): Mus Musculus 
2026-03-11 | PXD075525 |
ProteomicsThe Interactome of SARS-CoV-2 Membrane protein
The interactome of SARS-CoV-2 Membrane protein in HEK193T cells
ORGANISM(S): Homo Sapiens 
PXD065198 |
ProteomicsThe Dynll1-Cox4il Complex Regulates Intracellular Pathogen Clearance via Release of Mitochondrial Reactive Oxygen Species
Cellular membrane proteins are a critical part of the host defense mechanisms against infection and intracellular survival of Listeria monocytogenes. The complex spatiotemporal regulation of bacterial infection by various membrane proteins has been challenging to study. Here, using mass spectrometry...
ORGANISM(S): Mus Musculus 
2020-02-17 | PXD016452 |
ProteomicsQuantitative phosphoproteomic analysis of overexpressing PPP1R12B and control Huh7 cells samples using 4D-SmartDIA
Quantitative phosphoproteomic analysis of overexpressing PPP1R12B and control Huh7 cells samples using 4D-SmartDIA.
ORGANISM(S): Homo Sapiens 
PXD064803 |
ProteomicsHMGB2 promote ESCC tumorigenesis and predict neoadjuvant therapy response
Recent studies have demonstrated that chronic stress can enhance the development of multiple human diseases, including cancer. However, the role of chronic stress in esophageal carcinogenesis and its underlying molecular mechanisms remain unclear. This study uncovered that dysregulated cholesterol m...
ORGANISM(S): Mus Musculus 
2025-01-09 | PXD059616 |
ProteomicsChronic stress-induced cholesterol metabolism abnormalities promote ESCC tumorigenesis and predict neoadjuvant therapy response
chronic stress activates the GCR-HMGB2-LDLR axis via cortisol release, leading to abnormal cholesterol metabolism and ultimately promoting esophageal carcinogenesis
ORGANISM(S): Homo Sapiens 
2025-01-09 | PXD059578 |
ProteomicsThe subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3
The subcortical maternal complex (SCMC) is essential for the maintenance of female fertility in mammals. Most pathogenic mutations in SCMC-encoding genes result in female reproductive failure characterized by early embryonic arrest. Assembled in oocytes, the SCMC maintains the normal cleavage of ear...
ORGANISM(S): Mus Musculus Spodoptera Frugiperda 
PXD055498 |
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