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TranscriptomicsMapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription
Insulin (INS) synthesis and secretion from pancreatic M-NM-2 cells are tightly regulated; their deregulation causes diabetes. Here we map INS-associated loci in human pancreatic islets by 4C and 3C techniques and show that the INS gene physically interacts with the SYT8 gene, located over 300 kb ...
ORGANISM(S): Homo sapiens 
2011-02-22 | E-GEOD-25862 | biostudies-arrayexpress
ProteomicsThe MbovP280 of mycoplasma bovis immunoprecipitates with the wole cell lysates of bovine macrophage (BoMac),and then LC-MS/MS was used to identify the MbovP280-binding ligands
An IP–MS method was used to screen for MbovP280-binding proteins. Briefly, BoMac cells were cultured, harvested, and lysed in RIPA buffer supplemented with cOmplete Protease Inhibitor Cocktail (Roche, Mannheim, Germany). The whole-cell lysates (400 μg) were incubated with 10 μg of either rMbovP280 o...
ORGANISM(S): Bos taurus (Bovine) 
2021-09-09 | PXD022080 | Pride
Lc-ms/ms Bomac Bovine Ip Mycoplasma bovis Mbovp280 
UnknownPromoter polymorphism of MRP1 associated with reduced survival in hepatocellular carcinoma.
Not available
S-EPMC3012574 | biostudies-literature
ProteomicsThe Pharmacological Effect and Mechanism of Lanthanum Hydroxide on Vascular Calcification Caused by Chronic Renal Failure Hyperphosphatemia
Objective: To investigate the treatment and mechanism of lanthanum hydroxide on hyperphosphate-induced vascular calcification in chronic renal failure. Methods: Develop a rat model of CKD hyperphosphatemia. Rats were randomly allocated to the model, lanthanum hydroxide, lanthanum carbonate, Calcium...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-09 | PXD023081 | Pride
Hyperphosphatemia Vascular calcification Lanthanum hydroxide Mechanism Pharmacological effect Chronic renal failure 
ProteomicsMass spectrometry analysis of Extracellular vesicles derived from naive HUVEc cells or ZIKV-infected HUVEc cells
In this project, we aimed to explore the role of extracellular vesicles (EVs) in Zika virus (ZIKV) infection. We preferred antibody capture to ltracentrifugation for exosome isolation. The EVs derived from naive HUVEc cells or ZIKV-infected HUVEc cells were harvested and analyzed by mass spectrometr...
ORGANISM(S): Homo sapiens (Human) 
2023-01-19 | PXD039152 | Pride
Mass specctrometry Extracellular vesicles Zikv infection 
TranscriptomicsDetection of single nucleotide variations in expressed exons of the human genome using RNA-Seq
Whole genome re-sequencing is still a costly method to detect genetic mutations that lead to altered forms of proteins and may be associated with disease development. Since the majority of disease-related single nucleotide variations (SNVs) are found in protein-coding regions, we propose to identify...
ORGANISM(S): Homo sapiens 
2009-06-15 | E-GEOD-16190 | biostudies-arrayexpress
UnknownProteomicsBrowser: MS/proteomics data visualization and investigation.
Not available
S-EPMC6596887 | biostudies-literature
TranscriptomicsComparison of transcriptome profile between wild-type and dao mutant plants
We identified and characterized that the rice Dioxygenase for Auxin Oxidation (dao) mutant displays pleiotropic phenotypes, including indehiscent anthers, sterile pollens, and increased free IAA levels in anthers.We conclude that DAO-mediated auxin catabolism is essential for auxin homeostasis and l...
ORGANISM(S): Oryza sativa Japonica Group 
2012-09-25 | E-GEOD-41097 | biostudies-arrayexpress
UnknownAssociation between cardiometabolic index and self-reported symptoms of obstructive sleep apnea: a cross-sectional study.
Not available
S-EPMC12325783 | biostudies-literature
GenomicsGenome-wide mapping of REST-bound sites in human CD4+ T cells
We performed ChIP-seq to identify genome-wide REST (NRSF) binding in the human CD4+ T cells. The data were compared to REST occupancy in additional 15 human cell types analyzed by the ENCODE project (GSE32465) in order to study the dynamics and context-dependent functions of REST-chromatin interacti...
ORGANISM(S): Homo sapiens 
2014-08-06 | E-GEOD-49570 | biostudies-arrayexpress
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