Sort   by:  
 Page size 
ProteomicsHuman liver cell line LO2 LC-MS/MS
A hyperlipidaemia model of L02 cells was established using free fatty acids (FFA, oleate and palmitate, 2:1; Sigma-Aldrich, USA) at a final concentration of 1 mM for 24 h. Cells were allowed to attach overnight prior to HTG-medicated serum for 24 h and then exposed to FFA during drug treatment. Afte...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD045069 | Pride
Human Liver cell Lc-ms/ms 
ProteomicsHEK293T cells were transfected with Flag-tagged NLRP3 treated with or without nigericin (10 μM, 1 h).
In order to identificate NLRP3 acetylation, we utilized an acetylproteomic approach to identify the acetylation sites within NLRP3. We first reconstituted the NLRP3 inflammasome in HEK293T cells by co-transfected with plasmids encoding NLRP3, ASC, Caspase-1 and Pro-IL-1β, then stimulated the genetic...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-25 | PXD041763 | Pride
Hek293tcells， nlrp3 
ProteomicsHK-2 cells 4D label quantitative lactylproteomic analysis
Following acute kidney injury (AKI), a substantial subset of patients experiences an irreversible progression to chronic kidney disease (CKD), yet the molecular determinants governing this maladaptive transition remain elusive, and effective clinical interventions are lacking. Here, we identify lact...
ORGANISM(S): Homo sapiens (Human) 
2026-07-18 | PXD078736 | Pride
Human  lactylation 
ProteomicsSerum proteomics of wild type mice and Mdm2 adipocyte-specific knock-in mice fed high-fat diet
The serum samples from wild type mice fed high-fat diet for 12 weeks (WT_Serum) and Mdm2 adipocyte-specific knock-in mice fed high-fat diet for 12 weeks (KI_Serum) were mixed separately, and subjected to proteomic study by Label-free quantitative techniques and mass spectrometry-based proteomics tec...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-11 | PXD034069 | Pride
Serum Proteomics Mice Wild type Mdm2 
UnknownMapping the N-linked glycosites of rice (Oryza sativa L.) germinating embryos.
Not available
S-EPMC5362090 | biostudies-literature
ProteomicsThe eWAT proteomics of wild type mice and Mdm2 adipocyte-specific knock-in mice fed high-fat diet
The epididymal adipose tissue (eWAT) samples from wild type mice fed high-fat diet for 12 weeks (H_WT_E) and Mdm2 adipocyte-specific knock-in mice fed high-fat diet for 12 weeks (H_KI_E) were mixed separately, and subjected to proteomic study by Label-free quantitative techniques and mass spectromet...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-11 | PXD034074 | Pride
Proteomics Ewat Mice Mdm2 High-fat diet 
UnknownHistone acetyltransferase 1 is a succinyltransferase for histones and non-histones and promotes tumorigenesis.
Not available
S-EPMC7857430 | biostudies-literature
UnknownHMCDA: a novel method based on the heterogeneous graph neural network and metapath for circRNA-disease associations prediction.
Not available
S-EPMC10494331 | biostudies-literature
ProteomicsVec-STING LS-MS and US2 STING LS-MS
Since US2 causes STING to be degraded through ubiquitination, we aimed to find any ubiquitin enzymes that might be implicated in this action.
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD053353 | Pride
Sting Us2 
ProteomicsKu80 lysine crotonylation conversion to SUMOylation facilitates DNA non-homologous end joining and cellular resistance to radiation
A DNA double-strand break (DSB) is the most serious DNA damage and is also the principal molecular basis of radiotherapy. Upon DNA damage, the Ku80 is recruited and forms a critical DNA-PK complex at the DSB sites with Ku70 and the catalytic subunit (DNA-PKcs) to initiate DNA repair. How DNA-PK is a...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD061039 | Pride
Dna double-strand break repair  ku80  crotonylation  sumoylation  dna-pk holoenzyme assembly  radioresistance 
Sort   by:  
 Page size