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ProteomicsMulti-Omics Analysis Reveals Alcohol exposure affects Ferroptosis pathway in Brain
Alcohol-related brain damage (ARBD) constitutes a major global public health issue and is often comorbid with neuropsychiatric disorders such as Alzheimer's and Parkinson's diseases. Ferroptosis, a form of regulated cell death characterized by iron dependency and lipid peroxidation, has been implica...
ORGANISM(S): Mus Musculus 
2026-03-11 | PXD075525 |
ProteomicsThe Interactome of SARS-CoV-2 Membrane protein
The interactome of SARS-CoV-2 Membrane protein in HEK193T cells
ORGANISM(S): Homo Sapiens 
PXD065198 |
ProteomicsGenome-wide identification and proteomic analysis of the wheat ABCG family reveals a pivotal role of TaABCG7B-8 in fertility conversion of a photoperiod-temperature sensitive genic male sterility wheat
Photoperiod- and temperature-sensitive genic male sterility (PTGMS) plays a central role in two-line hybrid wheat breeding, yet its underlying molecular mechanisms remain incompletely understood. In this study, we performed a genome-wide identification of the ATP-binding cassette subfamily G (ABCG) ...
ORGANISM(S): Triticum Aestivum 
2026-01-04 | PXD072615 |
ProteomicsQuantitative phosphoproteomic analysis of overexpressing PPP1R12B and control Huh7 cells samples using 4D-SmartDIA
Quantitative phosphoproteomic analysis of overexpressing PPP1R12B and control Huh7 cells samples using 4D-SmartDIA.
ORGANISM(S): Homo Sapiens 
PXD064803 |
ProteomicsHMGB2 promote ESCC tumorigenesis and predict neoadjuvant therapy response
Recent studies have demonstrated that chronic stress can enhance the development of multiple human diseases, including cancer. However, the role of chronic stress in esophageal carcinogenesis and its underlying molecular mechanisms remain unclear. This study uncovered that dysregulated cholesterol m...
ORGANISM(S): Mus Musculus 
2025-01-09 | PXD059616 |
ProteomicsChronic stress-induced cholesterol metabolism abnormalities promote ESCC tumorigenesis and predict neoadjuvant therapy response
chronic stress activates the GCR-HMGB2-LDLR axis via cortisol release, leading to abnormal cholesterol metabolism and ultimately promoting esophageal carcinogenesis
ORGANISM(S): Homo Sapiens 
2025-01-09 | PXD059578 |
ProteomicsArginine methylation of METTL14 promotes RNA N6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells
m6A is the most abundant modification of mRNA in mammals and plays an important role in human development and disease. METTL14 is a key component of m6A methyltransferase complex. The project showed that its post-translational arginine methylation can regulate the generation of m6A and the endoderm ...
ORGANISM(S): Homo Sapiens 
PXD018458 |
ProteomicsProteogenomic landscape of the Esophageal Squamous Cell Cancer reveals the lipid droplet formation process as a novel therapeutic target
The integrated proteogenomic analysis revealed proteomic characteristics associated with genomic variants and clinical features including arm or focal amplifications, SNV mutations, tumor size, lymph node metastasis, smoking history.
ORGANISM(S): Homo Sapiens 
2025-03-24 | PXD062163 |
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