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Skeletal muscle senescence influences whole organism aging, yet little is known on the relay of pro-longevity signals from muscles to other tissues. We performed an RNAi screen in Drosophila for muscle-released cytokines ('myokines') regulating lifespan and identified Myoglianin, the homolog of huma...
ORGANISM(S): Drosophila melanogaster 
Brachylophosaurus canadensis peptides from blood vessels isolated from within the bone were characterized using high resolution mass spectrometry. This allowed identification of actin, alpha and beta tubulin, various histones, myosin, and tropomyosin. Within the peptides, evidence of age (e.g., deam...
ORGANISM(S): Struthio camelus (Ostrich) Gallus gallus (Chicken) Brachylophosaurus canadensis (Campanian hadrosaur) 
2015-11-30 | PXD001738 | Pride
Genetic and epigenetic alterations are a fundamental aspect of colorectal cancer formation. There is considerable heterogeneity between colorectal cancers regarding the mutations and methylated genes they carry, and this heterogeneity may arise early in the polyp-cancer sequence. However, our unde...
ORGANISM(S): Homo sapiens 
Respiratory syncytial virus (RSV), along with other prominent respiratory RNA viruses such as influenza and SARS-CoV-2, significantly contributes to the global incidence of respiratory tract infections. These pathogens induce the production of reactive oxygen species (ROS), which play a crucial role...
ORGANISM(S): Homo sapiens (Human) Human respiratory syncytial virus A 
2024-10-09 | PXD053262 | Pride
Triplicates preparations of RNA from day 10 DC's. Experiment is described in Wong et al 2003 Nat. Immunol.
ORGANISM(S): Mus musculus 
The objective of the study was to identify differentially methylated regions of DNA (DMRs) that distinguish human leukocyte subtypes, and hence serve as biomarkers for those immune cell types. This file contains Illumina Infinium HumanMethylation27 BeadChip data for human leukocyte subtypes that wer...
ORGANISM(S): Homo sapiens 
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