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ProteomicsSpatial Proteomics Profiling of Vascular Smooth Muscle Cells and Atherosclerotic Plaques in a Diabetic Atherosclerosis Mouse Model
This project presents a spatial proteomic investigation of vascular smooth muscle cells (VSMCs) and atherosclerotic plaque regions in a diabetic mouse model of atherosclerosis (DMAS). Using ApoE-/- mice fed with a high-fat diet and treated with low-dose streptozotocin (STZ) to induce a diabetic phen...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-29 | PXD063231 | Pride
Diabetes mellitus  atherosclerosis  spatial proteomic technology 
MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
UnknownStructure and mechanism of the phycobiliprotein lyase CpcT.
Not available
S-EPMC4175310 | biostudies-literature
ProteomicsProteomic analysis of the invasiveness of human bladder cancer cells
To identification of key drivers involved in the development of muscle invasive bladder cancer, which displays poor prognosis, we isolated one subpopulation of human 5637 bladder cancer cells with highly invasiveness and the other subpopulation of 5637 cells with low invasiveness by Transwell method...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-08-27 | MSV000082854 | MassIVE
ProteomicsProteomic profiling and tumor microenvironment characterization reveal molecular and immunological hallmarks of left-sided and right-sided colon cancer tumorigenesis
The protein landscapes of LSCC and RSCC were constructed, and the hallmarks of tumorigenesis and characteristics of TME for LSCC and RSCC were identified. These findings improved our understanding of LSCC and RSCC and may facilitate the development of diagnostic or therapeutic targets for LSCC and R...
ORGANISM(S): Homo Sapiens 
PXD042962 |
MetabolomicsCancer-cell-secreted exosomal miR-105 promotes tumour growth through the Myc-dependent metabolic reprogramming of stromal cells
Cancer and other cells residing in the same niche engage various modes of interactions to synchronize and to buffer the negative effects of environmental changes. Extracellular miRNAs have been recently implicated in the intercellular crosstalk. Here we show a mechanistic model involving breast-canc...
2018-07-10 | MTBLS626 | MetaboLights
ProteomicsPlasma proteomics dataset of COVID-19 patients
Quantitative proteomic analysis of plasma from different time courses of fatal, severe, and mild COVID-19 patients was performed to assess the biological changes during treatment.
ORGANISM(S): Homo Sapiens 
PXD019106 |
ProteomicsPhysiological and proteomic analysis responsive mechanisms for salt stress in oat
Oat is considered as a moderately salt-tolerant crop that can be used to improve saline and alkaline soils. Previous studies have focused on short-term salt stress exposure, and the molecular mechanisms of salt tolerance in oat have not yet been elucidated. In this study, the salt-tolerant oat varie...
ORGANISM(S): Oryza Sativa 
PXD034203 |
ProteomicsRoles of USP2/E2F4 axis in autophagic machinery essential for cancer progression
We investigated the potential proteins degraded by E2F4-induced autophagy via quantitative proteomics. To gain insight into protein partner essential for E2F4 stability, co-immunoprecipitation and mass spectrometry assays were performed.
ORGANISM(S): Homo Sapiens 
2021-11-19 | PXD029858 |
ProteomicsMass spectrometry of HCT116 cells
HCT116 cells were transfected with flag-pcDNA3.1 plasmids or flag-MST3 plasmids. Whole-cell extracts were prepared with a lysis buffer, lysed on ice for 10 min, centrifuged at 12,000 rpm for 10 min at 4°C, and the supernatant was collected. The anti-Flag antibody and protein A/G beads were added and...
ORGANISM(S): Homo Sapiens 
2024-03-09 | PXD050513 |
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