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We profiled the global cellular proteome of WT, PFDN3 knockout, and PFDN4 knockout cells using label-free quantification (LFQ) mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD056198 | Pride
Cathepsin D is reportedly to be closely associated with tumor development, migration and invasion, but its pathological mechanism is not fully elucidated. We aimed to evaluate phenotypic changes and molecular events in response to cathepsin D knockdown. Lowering endogenous cathepsin D abundance (CR)...
ORGANISM(S): Homo sapiens (Human) 
2015-12-17 | PXD002844 | Pride
Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning
ORGANISM(S): Mus Musculus 
2023-10-24 | PXD046337 |
Although the inhibitor of apoptosis protein-like protein-2 (ILP-2) is regarded as a novel growth enhancer for breast cancer, its mechanism on breast cancer cell growth remains elusive and requires further study. In this study, isobaric tags were applied for relative and absolute quantification (iTRA...
ORGANISM(S): Homo Sapiens 
2019-02-25 | PXD012848 |
LVTX-8, a peptide toxin synthesized from the cDNA library of the spider Lycosa vittata with 25 amino acids. In this study, we performed a series of cellular and molecular experiments such as cell toxicity, colony formation, and cell migration assays to exam the anticancer activity, selectivity and e...
ORGANISM(S): Homo Sapiens 
2024-03-11 | PXD050542 |
Despite advances in the development of direct KRAS inhibitors, KRAS-mutant cancers continue to exhibit resistance to the currently available therapies. Here, we identified REGγ as a mutant KRAS-associated factor that enhances REGγ transcription through the KRAS intermediate NRF2, suggesting that the...
ORGANISM(S): Homo Sapiens 
2025-01-01 | PXD059364 |
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