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TranscriptomicsRole of zyxin in the tension-induced expression change in endothelial cells
One of the hallmarks in hypertension is a pressure-induced change in endothelial cell phenotype. A cytoskeletal protein zyxin, which was seen to translocate from focal adhesion contacts to the nucleus in response to the increased wall tensionis, mediates the tension-induced endothelial signaling. Mi...
ORGANISM(S): Homo sapiens 
2010-08-16 | E-GEOD-17814 | biostudies-arrayexpress
ProteomicsProteolysis of zyxin by HtrA1 induces nuclear translocation of the resulting C-terminal fragment of zyxin
We identified two neo-N termini derived from proteolytic cleavage of the mechanotransducer zyxin at Asp149 and Val276. We correlated these proteolytic events with the activity of caspase-1 and serine protease HtrA1, respectively, and observed nuclear translocation of the fragment zyxin277-572. To ev...
ORGANISM(S): Homo sapiens (Human) 
2020-09-07 | PXD017432 | Pride
Zyxin Tmt Hela Lc-ms/ms 
TranscriptomicsStretch-dependent genes in vascular smooth muscle cells
Vascular smooth muscle cells (VSMCs) respond to biomechanical stretch with specific changes in gene expression which govern the phenotype of these cells. The mechanotransducer zyxin is a potential candidate for regulating the expression of such genes. Using microarrays, we compared stretch-induced ...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-60447 | biostudies-arrayexpress
ProteomicsAnalysis of Zyxin's interactome and phosphosites in early Xenopus laevis development by Data-Independent Acquisition proteomics
Protein complexes are key players in development, functioning as molecular machines whose proper assembly is crucial for numerous cellular processes. Their formation at the correct time and location is facilitated by specialized scaffold proteins. A prominent example is the mechanosensitive cytoskel...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2026-02-02 | PXD071213 | Pride
Zyxin Xenopus laevis. lc-ms 
ProteomicsComparative protein profiling of wild type and zyxin knockout podocytes
Podocyte detachment due to mechanical stress is a common issue in hypertension-induced kidney disease. The present study investigated the role of zyxin in mechanically stretched podocytes, a model for glomerular hypertension. Conditionally immortalized differentiated podocytes were seeded on flexibl...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-30 | PXD050861 | Pride
Podocytes Zyxin knockout Mechanical stretch Lc-ms/ms 
ProteomicsAnalysis of Zyxin's interactome and phosphosites in early Xenopus laevis development by Data-Dependent Acquisition proteomics
Protein complexes are key players in development, functioning as molecular machines whose proper assembly is crucial for numerous cellular processes. Their formation at the correct time and location is facilitated by specialized scaffold proteins. A prominent example is the mechanosensitive cytoskel...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2026-02-02 | PXD071283 | Pride
Lc-msms Xenopus laevis Zyxin 
TranscriptomicsTead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-03-12 | E-GEOD-55711 | biostudies-arrayexpress
TranscriptomicsTead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition (expression)
Cellular changes during an epithelial-mesenchymal transition (EMT) largely rely on global changes in gene expression orchestrated by transcription factors. Tead transcription factors and their co-factors Yap and Taz have been shown to be implicated in EMT, nevertheless, their direct and indirect tar...
ORGANISM(S): Mus musculus 
2014-03-12 | E-GEOD-55710 | biostudies-arrayexpress
TranscriptomicsRole of zyxin in the tension-induced expression change in endothelial cells
One of the hallmarks in hypertension is a pressure-induced change in endothelial cell phenotype. A cytoskeletal protein zyxin, which was seen to translocate from focal adhesion contacts to the nucleus in response to the increased wall tensionis, mediates the tension-induced endothelial signaling. Mi...
ORGANISM(S): Homo sapiens 
2010-08-16 | GSE17814 | GEO
GenomicsTead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition (ChIP-seq)
Cellular changes during an epithelial-mesenchymal transition (EMT) largely rely on global changes in gene expression orchestrated by transcription factors. Tead transcription factors and their co-factors Yap and Taz have been shown to be implicated in EMT, nevertheless, their direct target genes dur...
ORGANISM(S): Mus musculus 
2014-03-12 | E-GEOD-55709 | biostudies-arrayexpress
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