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ProteomicsGluten-specific antibodies of celiac disease gut plasma cells recognize long proteolytic fragments that typically harbor T-cell epitopes
This study aimed to identify proteolytic fragments of gluten proteins recognized by recombinant IgG1 monoclonal antibodies generated from single IgA plasma cells of celiac disease lesions. Peptides bound by monoclonal antibodies in complex gut-enzyme digests of gluten treated with the deamidating en...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080779 | MassIVE
ProteomicsSARS-COV-2 Uses CD4 to infect T Helper Lymphocytes
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or CoV-2) is the agent of a major global outbreak of respiratory tract disease known as COVID-19. CoV-2 infects the lungs and may cause several immune-related complications such as lymphocytopenia and cytokine storm which are associated...
ORGANISM(S): Homo sapiens (Human) 
2023-07-28 | PXD020967 | Pride
Lc-msms T-cell Sars-cov-2 infection Proteomics 
TranscriptomicsMesenchymal Stem Cells Promote the Sustained Expression of CD69 on Activated T-lymphocytes: Roles of Canonical and Non-Canonical NF-κB Signaling
Mesenchymal stem cells (MSCs) are known to induce the conversion of activated T-cells into regulatory T-cells in vitro. The marker CD69 is a target of canonical NF-κB signaling and is transiently expressed upon activation; however, stable CD69 expression defines cells with immunoregulatory propertie...
ORGANISM(S): Homo sapiens 
2011-08-02 | E-GEOD-31153 | biostudies-arrayexpress
MetabolomicsMetabolite profiling of Arabidopsis mutants of enzymes of lower glycolysis
We have previously shown that in Arabidopsis the three enzymes of lower glycolysis phosphoglycerate mutase (PGAM), enolase and pyruvate kinase form a complex which play an important role in co-sub-cellar localization the mitochondria to the chloroplast. Given that their metabolites of these mutants,...
2022-10-10 | MTBLS4066 | MetaboLights
ProteomicsDifferent Binding Motifs of the Celiac Disease Associated HLA Molecules DQ2.5, DQ2.2 and DQ7.5 Revealed by Relative Quantitative Proteomics of Endogenous Peptide Repertoires
In this study relative quantitative analysis of endogenous peptides by mass spectrometry combined with neural network analysis have been used to address why the alpha- or beta-chain sharing human leukocyte antigen (HLA)-DQ molecules DQ2.5, DQ2.2 and DQ7.5 display different risks for celiac disease. ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080859 | MassIVE
UnknownTriatoma guazu Lent and Wygodzinsky Is a Junior Synonym of Triatoma williami Galvao, Souza and Lima.
Not available
S-EPMC9318919 | biostudies-literature
ProteomicsP2X7 signaling drives Th1 cell differentiation through metabolic reprogramming for aerobic glycolysis
This study provides evidence on the molecular mechanisms by which P2RX7 signaling promotes Th1 cell differentiation. P2RX7 induces T-bet expression and aerobic glycolysis in splenic CD4+ T cells that respond to malaria, at a time prior to Th1/Tfh polarization. Cell-intrinsic P2RX7 signaling sustains...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-08 | PXD037754 | Pride
Aerobic glycolysis Malaria P2x7 signaling Th1 cell differentiation 
ProteomicsGluten-specific antibodies of celiac disease gut plasma cells recognize long proteolytic fragments that typically harbor T-cell epitopes
This study aimed to identify proteolytic fragments of gluten proteins recognized by recombinant IgG1 monoclonal antibodies generated from single IgA plasma cells of celiac disease lesions. Peptides bound by monoclonal antibodies in complex gut-enzyme digests of gluten treated with the deamidating en...
ORGANISM(S): Homo sapiens (Human) 
2016-05-10 | PXD002678 | Pride
Lc-msms Celiac disease Gliadin Monoclonal antibodies Epitopes 
UnknownPhenotypic Characterization of CD4+ T Lymphocytes in Periportal Fibrosis Secondary to Schistosomiasis.
Not available
S-EPMC7937650 | biostudies-literature
UnknownTranslating Unconventional T Cells and Their Roles in Leukemia Antitumor Immunity.
Not available
S-EPMC7808823 | biostudies-literature
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