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TranscriptomicsRNA-seq of young and senescent human umbilical vein endothelial cells (HUVECs) under normal or high glucose conditions
Human endothelial cellular models are useful to disentangle the pathophysiological role of dysfunctional endothelium in the development of cardiovascular (CV) disease and organ damage in T2D. Here, we performed a RNAseq of human umbilical vein endothelial cells (HUVECs) undergoing replicative senesc...
ORGANISM(S): Homo sapiens 
2024-04-08 | E-MTAB-13959 | biostudies-arrayexpress
TranscriptomicsRNAseq of effects of high glucose environment on differentiated primary osteoblasts
The aim of this study was to investigate the global transcriptional changes induced by high glucose environment in primary osteoblasts in vitro. We isolated bone marrow stromal cells from 4-week-old Sprague-Dawley rats, differentiated them into osteoblasts and exposed them to a short- (one or three ...
ORGANISM(S): Rattus norvegicus 
2024-05-13 | E-MTAB-13888 | biostudies-arrayexpress
GenomicsRNAseq of effects of high glucose environment on differentiated primary osteoblasts
RNAseq of effects of high glucose environment on differentiated primary osteoblasts
PRJEB73600 | ENA
TranscriptomicsGene-environment interaction in yeast gene expression
This study is a quantitative trait linkage mapping study targeted at gene-environment interaction. A family of yeast derived from BY4716 and RM11-1a was grown in two carbon sources (glucose and ethanol) and expression profiled. The analysis revealed how the influence of genetic factors changes in di...
ORGANISM(S): Saccharomyces cerevisiae 
2008-04-15 | E-GEOD-9376 | biostudies-arrayexpress
GenomicsHigh-glucose environment impairs keratinocyte migration and proliferation through the ROS/Akt/ETV4 signaling pathway
High-glucose environment impairs keratinocyte migration and proliferation through the ROS/Akt/ETV4 signaling pathway
PRJNA1334327 | ENA
ProteomicsDynamic changes in the protein localization in the nuclear environment in pancreatic β-cell after brief glucose stimulation
We focus on the characterization of proteins in the nuclear environment of β-cells after brief, high glucose-stimulation. We compared purified nuclei derived from β-cells stimulated with 17mM glucose for 0, 2, and 5 minutes using quantitative proteomics, a time frame that most likely does not result...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2018-03-12 | PXD008988 | Pride
Lc-msms Pancreatic beta-cells Gsis Nucleus 
TranscriptomicsTranscription profiling of mouse mesangial cell line MES-13 to examine the global effects of high glucose (HG) and glucosamine (GlcN) on the transcriptome.
The renal mesangial cells play an important role in the development of diabetic glomerulosclerosis and renal failure. We have previously demonstrated some of the effects of high glucose are mediated via the hexosamine biosynthesis pathway (HBP) in which fructose-6-phosphate is converted to glucosami...
ORGANISM(S): Mus musculus 
2007-12-01 | E-GEOD-2557 | biostudies-arrayexpress
TranscriptomicsSevere alkaline pH stress induces a glucose starvation-related transcriptional response in S. cerevisiae
Alkaline pH stress invokes in S. cerevisiae a potent and fast transcriptional response that includes many genes repressed by glucose. Certain mutants in the glucose-sensing and response pathways, such as those lacking the Snf1 kinase, are sensitive to alkalinization. We show that addition of glucose...
ORGANISM(S): Saccharomyces cerevisiae 
2012-03-02 | E-GEOD-25697 | biostudies-arrayexpress
TranscriptomicsFunctional genomic analysis of a commercial wine strain of Saccharomyces cerevisiae under differing nitrogen conditions.
DNA microarray analysis was used to profile gene expression in a commercial isolate of Saccharomyces cerevisiae grown in a synthetic grape juice medium under conditions mimicking a natural environment for yeast: High-sugar and variable nitrogen conditions. The high nitrogen condition displayed eleva...
ORGANISM(S): Saccharomyces cerevisiae 
2006-05-23 | E-GEOD-4887 | biostudies-arrayexpress
TranscriptomicsDeterminants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populations
Divergent adaptation can be associated with reproductive isolation in the process of speciation. We recently demonstrated the link between divergent adaptation and the onset of reproductive isolation in experimental populations of the yeast Saccharomyces cerevisiae evolved from a single progenitor ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-07-15 | E-GEOD-20943 | biostudies-arrayexpress
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