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UnknownGlutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy.
Cancer cells can evade immune surveillance through the expression of inhibitory ligands that bind their cognate receptors on immune effector cells. Expression of programmed death ligand 1 in tumor microenvironments is a major immune checkpoint for tumor-specific T cell responses as it binds to progr...
S-EPMC7025889 | biostudies-literature
UnknownCD47-SIRPα Checkpoint Inhibition Enhances Neutrophil-Mediated Killing of Dinutuximab-Opsonized Neuroblastoma Cells.
High-risk neuroblastoma, especially after recurrence, still has a very low survival rate. Immune checkpoint inhibitors targeting T cells have shown remarkable clinical efficacy in adult solid tumors, but their effects in pediatric cancers have been limited so far. On the other hand, targeting myeloi...
S-EPMC8428220 | biostudies-literature
UnknownSIRPα on Mouse B1 Cells Restricts Lymphoid Tissue Migration and Natural Antibody Production.
The inhibitory immunoreceptor SIRPα is expressed on myeloid and neuronal cells and interacts with the broadly expressed CD47. CD47-SIRPα interactions form an innate immune checkpoint and its targeting has shown promising results in cancer patients. Here, we report expression of SIRPα on B1 lymphocyt...
S-EPMC7581795 | biostudies-literature
ProteomicsMKL1 deficiency results in a neutrophil motility defect with impaired actin polymerization and excessive degranulation
Megakaryoblastic leukemia 1 (MKL1) promotes the regulation of essential cell processes, including actin cytoskeletal dynamics by co-activating serum response factor. Recently, the first human case with MKL1 deficiency has been identified, leading to a novel primary immunodeficiency. We report a seco...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD014633 | Pride
Mkl1 Actin poymerization Neutrophils Srf Mrtf-a 
ProteomicsPU1 interactome in human monocyte derived dendritic cells
Human monocyte-derived DC were cultured at a density of 0.5x10E6 cells/ml in RPMI-1640 supplemented with 10% FCS, 1% Pen/Strep, 10 ng/ml GM-CSF and 10 ng/ml IL4. At day 7, they were stimulated or not with 500 ng/ml LPS. Cells were collected at day 10. Whole cell lystaes from 2x10E8 cells were used f...
ORGANISM(S): Homo Sapiens 
2018-11-30 | MSV000083175 | MassIVE
ProteomicsPU.1 interactome mouse bone marrow derived dendritic cells
Mouse bone marrow derived dendritic cells were generated by culturing bone marrow cells at a density of 0.5x10E6 cells/ml in RPMI-1640 supplemented with 5% FCS, 1% Pen/Strep, 5microM 2-mercaptoethanol, 20ng/ml GM-CSF. At day 7 dendritic cells were stimulated or not with 500 ng/ml LPS, and collected ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-11-30 | MSV000083176 | MassIVE
UnknownComparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry.

Background and purpose

Prospectively collected data comparing the safety and effectiveness of individual non-vitamin K antagonists (NOACs) are lacking. Our objective was to directly compare the effectiveness and safety of NOACs in patients with newly diagnosed atrial fibrillation (AF).

Me...

S-EPMC9054878 | biostudies-literature
ProteomicsA Comprehensive Proteomics Study on Platelet Concentrates: Platelet Proteome, Storage Time and Mirasol Pathogen Reduction Technology
Platelet concentrates (PCs) represent a blood transfusion product with a major concern for safety as their storage temperature (20-24ºC) allows bacterial growth, and their maximum storage time period (less than a week) precludes complete microbiological testing. Pathogen inactivation technologies (P...
ORGANISM(S): Homo sapiens (Human) 
2018-03-23 | PXD008119 | Pride
Platelet function tests Storage time Platelet transfusion Pathogen inactivation technologies Blood safety Proteomics 
UnknownCD47-signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction.
Monoclonal antibodies are among the most promising therapeutic agents for treating cancer. Therapeutic cancer antibodies bind to tumor cells, turning them into targets for immune-mediated destruction. We show here that this antibody-mediated killing of tumor cells is limited by a mechanism involving...
S-EPMC3215076 | biostudies-literature
UnknownFcγRIIIb Restricts Antibody-Dependent Destruction of Cancer Cells by Human Neutrophils.
The function of the low-affinity IgG-receptor FcγRIIIb (CD16b), which is uniquely and abundantly expressed on human granulocytes, is not clear. Unlike the other Fcγ receptors (FcγR), it is a glycophosphatidyl inositol (GPI) -anchored molecule and does not have intracellular signaling motifs. Neverth...
S-EPMC6363688 | biostudies-literature
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