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ProteomicsSyntaxin-3 is a Weibel-Palade body localized SNARE protein that regulates Von Willebrand factor secretion from endothelial cells
Endothelial cells store von Willebrand factor (VWF) in rod-shaped secretory organelles, called Weibel-Palade bodies (WPBs). WPB exocytosis is coordinated by a complex network of Rab GTPases, Rab-effectors and SNARE proteins. We have previously identified STXBP1 as the link between the Rab27A-Slp4-a ...
ORGANISM(S): Homo sapiens (Human) 
2018-07-04 | PXD006176 | Pride
Endothelial cells Proteomics Weibel-palade body Snare machinery Syntaxin-3 Von willebrand factor 
ProteomicsIdentification of different human CD8 T cell subsets by superior cytotoxicity in human T cells
Cytotoxic CD8+ T cells can effectively kill target cells by producing cytokines, chemokines and granzymes. Expression of these effector molecules is however highly divergent, and tools that identify and pre-select potent killer cells are lacking. Human CD8+ T cells can be divided into IFNGand IL-2 p...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD012874 | Pride
Human Il2 Ifng Cd8 T cells 
ProteomicsDefective AP-3-dependent VAMP8 trafficking impairs Weibel-Palade body exocytosis in Hermansky-Pudlak Syndrome type 2 blood outgrowth endothelial cells.
Weibel-Palade bodies (WPBs) are endothelial secretory organelles that contain VWF, P-selectin and CD63. Release of VWF from WPBs is crucial for platelet adhesion during primary hemostasis. Endosomal trafficking of proteins like CD63 to WPBs during maturation is dependent on the AP-3 complex. Mutatio...
ORGANISM(S): Homo sapiens (Human) 
2019-01-31 | PXD011294 | Pride
Endothelial cells Weibel-palade bodies Hps2 Ap3 complex 
ProteomicsDynamic transcriptome-proteome correlation networks reveal human myeloid differentiation and neutrophil-specific programming
Human neutrophilic granulocytes form the largest pool of innate immune cells for host defense against bacterial and fungal pathogens. The dynamic changes that accompany the metamorphosis from a proliferating myeloid progenitor cell in the bone marrow into a mature non-dividing polymorphonuclear bloo...
ORGANISM(S): Homo sapiens (Human) 
2019-11-07 | PXD013785 | Pride
Transcriptomics Proteomics Neutriphils Myeloid differentiation 
ProteomicsQuantitative Proteomics Reveals Specialized Wiring of Signaling Pathways that Protects Human Regulatory T Cell Identity - 5 populations ex vivo
Regulatory CD4+ T cells (Tregs) are functionally distinct from conventional CD4+ T cells (Tconvs). To understand Treg identity, we compared by proteomics and transcriptomics human naïve (n) and effector (e)Tregs, Tconvs and transitional FOXP3+ cells. Only 12% of 422 differentially expressed proteins...
ORGANISM(S): Homo sapiens (Human) 
2018-05-18 | PXD005477 | Pride
Human Lfq Cd4+ t cells 
ProteomicsSyntaxin 5 determines Weibel-Palade body size and Von Willebrand factor secretion by controlling Golgi architecture
Abstract Von Willebrand factor (VWF) is a multimeric hemostatic protein primarily synthesized in endothelial cells (ECs). VWF is stored in endothelial storage organelles, the Weibel-Palade bodies (WPBs), whose biogenesis strongly depends on VWF anterograde trafficking and Golgi architecture. Elongat...
ORGANISM(S): Homo sapiens (Human) 
2022-01-27 | PXD027516 | Pride
Human Endothelial cells Weibel-palade bodies Von willebrand factor 
ProteomicsIn vitro erythropoiesis at different pO2 induces adaptations that are independent of prior systemic exposure to hypoxia
Hypoxia is associated with increased erythropoietin (EPO) release to drive erythropoiesis. However, a prolonged sojourn at high altitude results in an increase in EPO levels followed by a decrease, although erythropoiesis remains elevated at a stable level. The role of hypoxia and related EPO adjust...
ORGANISM(S): Homo sapiens (Human) 
2022-04-06 | PXD031776 | Pride
Human Lumos Erythropoiesis 
ProteomicsProteomic landscapes of inherited platelet disorders with different etiologies
Background: Inherited Platelet Disorders (IPDs) are a heterogeneous group of rare diseases that are caused by defects in early megakaryopoiesis, pro-platelet formation and/or mature platelet function. Although genomic sequencing is increasingly used to identify genetic variants underlying IPD, this ...
ORGANISM(S): Homo sapiens (Human) 
2023-01-31 | PXD027463 | Pride
Human Platelets Orbitrap fusion 
ProteomicsIntegrated proteomic analysis of Tumor Necrosis Factor α and Interleukin 1 β-induced endothelial inflammation
Objective The vascular endothelium provides a unique interaction plane for plasma proteins and leukocytes in inflammation. It has been established that particular proteins, including ICAM1, VCAM1 and SELE, are upregulated on the endothelial cell surface in the presence of pro-inflammatory cytokines ...
ORGANISM(S): Homo sapiens (Human) 
2018-09-03 | PXD009174 | Pride
Proteomics Inflammation Time-resolved Il-1β Phosphoproteomics Cell surface proteomics Endothelium Tnfα 
ProteomicsTissue-resident memory T cells maintain identity after in vitro restimulation
Resident memory T (TRM) cells have been recently established as an important subset of memory cells that provide early and essential protection against reinfection in the absence of circulating memory T cells. Recent findings showing that TRM expand in vivo after repeated antigenic stimulation indic...
ORGANISM(S): Mus musculus (Mouse) Listeria monocytogenes 
2025-09-30 | PXD041211 | Pride
Cd8+ memory t cells Tissue-resident memory t cells T cell metabolism Hypoxic t cell cultures 
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