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Multiple sclerosis (MS) is a neuroinflammatory disease characterized by expanding demyelinating lesions, leading to severe and irreversible disability.1–4 The mechanisms driving lesion expansion, however, remain poorly understood.5 Here, using a multi-omics approach, we identified foamy microglia le...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD056856 | Pride
In times of cellular stress, such as during virus infections, the integrated stress response (ISR) blocks translation initiation through phosphorylation of the essential translation initiation factor eIF2. Phosphorylated eIF2 (p-eIF2) sequesters the eIF2-specific guanidine exchange factor (GEF) eIF2...
ORGANISM(S): Homo sapiens (Human) 
2020-07-24 | PXD011879 | Pride
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