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ProteomicsCompartment resolved reference map from highly purified naive, activated, effector and memory CD8+ cells
Differentiation of CD8+ T lymphocytes into effector and memory cells is key for an adequate immune response and relies on complex interplay of pathways that convey signals from cell surface to nucleus. In this study, we fractionated four CD8+ T cell subtypes; naïve, recently activated effector, eff...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-02-29 | MSV000079540 | MassIVE
ProteomicsProteome data on the microbial microbiome of grasshopper feces
For phytophagous insects, the efficiency of utilization of hemicellulose and cellulose depends on the gut microbiota. Shifts in environmental and management conditions alter the presence and abundance of plant species which may induce adaptations in the diversity of gut microbiota. To test the adapt...
ORGANISM(S): Escherichia coli 
2017-01-02 | PXD005126 | Pride
Grasshoppers Metaproteomics Feces 
ProteomicsGut microbial functional maturation and succession during early life
The evolutional trajectory of gut microbial colonization from birth has been shown to prime for health later in life. Here, we combined cultivation-independent 16S rRNA gene sequencing and metaproteomics to investigate the functional maturation of gut microbiota in faecal samples from full-term heal...
ORGANISM(S): Homo sapiens (Human) 
2018-07-16 | PXD009056 | Pride
Gut microbiome  infants  metaproteomics  early life 
ProteomicsGlucocorticoid treatment leads to aberrant ion and macromolecular transport mechanisms in regenerating zebrafish fins.
Bone is a highly regenerative tissue but it can be permanently lost due to severe trauma and as a result of disease. In zebrafish, which are capable of complex organ regeneration, intramembranous bones of the fins and skull regenerate rapidly even after profound loss. The fin regenerate, albeit bein...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2019-09-26 | PXD013552 | Pride
Prednisolone Glucocorticoid Fin regeneration Q exactive hf Lable free quantification Lfq Zebrafish 
ProteomicsIdentification of protein-trichloroethene interactions during organohalide respiration revealed by thermal proteome profiling
The organohalide-respiring Sulfurospirillum multivorans uses chlorinated ethenes as electron acceptors for growth under anoxic conditions. However, little is known about the interaction of these substrates with proteins. Here, we apply thermal proteome profiling (TPP) to analyze enzyme-trichloroethe...
ORGANISM(S): Sulfurospirillum multivorans DSM 12446 
2018-06-06 | PXD009308 | Pride
Thermal proteome profiling (tpp)  interaction proteome  organohalide respiration  reductive dehalogenases  sulfurospirillum multivorans  dehalococcoides mccartyi  quantitative proteomics 
ProteomicsCompartment resolved reference map from highly purified naive, activated, effector and memory CD8+ cells
Differentiation of CD8+ T lymphocytes into effector and memory cells is key for an adequate immune response and relies on complex interplay of pathways that convey signals from cell surface to nucleus. In this study, we fractionated four CD8+ T cell subtypes; naïve, recently activated effector, effe...
ORGANISM(S): Mus musculus (Mouse) 
2015-02-04 | PXD001065 | Pride
Murine Cd8+ Lc-ms/ms 
ProteomicsProteomic characterization of CD34+ CD123+ stem cells from patients with acute myeloid leukemia
The comparative characterization of hematopoietic stem cells from healthy stem cell donors and patients with acute myeloid leukemia on a proteome level has the potential to reveal differentially regulated proteins which might be candidates for specific immunotherapy target molecules. Exemplarily, we...
ORGANISM(S): Homo sapiens (Human) 
2018-02-19 | PXD008378 | Pride
Proteomics Acute myeloid leukemia Lc-ms Aml 
ProteomicsProteomic characterization of the cellular effects of AHR activation by microbial tryptophan catabolites in endotoxin-activated human macrophages
Sensing of microbial tryptophan catabolites by the aryl hydrocarbon receptor (AhR) plays a pivotal role in host-microbiome homeostasis by modulating the host immune response. Thereby the involved cellular processes triggered by the metabolites are largely unknown. We analyzed proteomic changes in ma...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD025022 | Pride
Metabolism Lipopolysaccharides Proteomics Tmt Tryptophan catabolites Benzo[a]pyrene Indole-3-aldehyde Ahr Indole-3-acetic acide Human macrophages Lc-ms/ms 
ProteomicsAquifer metaproteomics - Candidate Brocadiales dominates C, N and S cycling in anoxic groundwater of a pristine limestone-fracture aquifer
Groundwater-derived microorganisms are known to play an important role in biogeochemical C, S and N cycling. Thereby, the presence and majorly the activity of microorganisms in aquifers affect enormously the nutrient cycling. However, the diversity and their functional capability in natural aquifers...
ORGANISM(S): Escherichia coli 
2016-12-23 | PXD004351 | Pride
Microbial community Groundwater Metaproteomics 
ProteomicsLC-MS/MS data of Sulfurospirillum multivorans
Organohalide respiration is an environmentally important but poorly characterized type of anaerobic respiration. We compared the global proteome of the versatile organohalide-respiring Epsilonproteobacterium Sulfurospirillum multivorans grown with different electron acceptors (fumarate, nitrate, or ...
ORGANISM(S): Sulfurospirillum multivorans DSM 12446 
2016-07-15 | PXD004011 | Pride
Organohalide respiration Epsilonproteobacterium Tetrachloroethene Proteomics 
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