Imageological/Structural Study regarding the Improved Pharmacokinetics by ⁶⁸Ga-Labeled PEGylated PSMA Multimer in Prostate Cancer.

ABSTRACT: PMSA (prostate-specific membrane antigen) is currently the most significant target for diagnosing and treating PCa (prostate cancer). Herein, we reported a series ⁶⁸Ga/¹⁷⁷Lu-labeled multimer PSMA tracer conjugating with PEG chain, including [⁶⁸Ga]Ga-DOTA-(1P-PEG₄), [⁶⁸Ga]Ga-DOTA-(2P-PEG₀), [⁶⁸Ga]Ga-DOTA-(2P-PEG₄), and [⁶⁸Ga]Ga/[¹⁷⁷Lu]Lu-DOTA-(2P-PEG₄)₂, which showed an advantage of a multivalent effect and PEGylation to achieve higher tumor accumulation and faster kidney clearance. To figure out how structural optimizations based on a PSMA multimer and PEGylation influence the probe's tumor-targeting ability, biodistribution, and metabolism, we examined PSMA m

SUBMITTER: Zhang H 

PROVIDER: S-EPMC10144514 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature