Association Between Serum Bilirubin and Atrial Fibrillation: A Mendelian Randomization Study.

ABSTRACT:

Background and objectives

The association between bilirubin and atrial fibrillation (AF) has been evaluated previously in observational studies but with contradictory results. This study evaluated the causal association between serum bilirubin level and AF using Mendelian randomization (MR) analysis.

Methods

This cross-sectional study includes 8,977 participants from the Dong-gu Study. In the observational analysis, multivariate logistic regression was performed to evaluate the association between bilirubin and prevalent AF. To evaluate the causal association between bilirubin and AF, MR analysis was conducted by using the UGT1A1 rs11891311 and rs4148323 polymorphisms as instrumental variables.

Results

Elevated serum bilirubin levels were associated with an increased

SUBMITTER: Kim SW 

PROVIDER: S-EPMC10406528 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature