Serum bilirubin and kidney function: a Mendelian randomization study.

ABSTRACT:

Background

Further investigation is needed to determine the causal effects of serum bilirubin on the risk of chronic kidney disease (CKD).

Methods

This study is a Mendelian randomization (MR) analysis. Among the well-known single-nucleotide polymorphisms (SNPs) related to serum bilirubin levels, rs4149056 in the SLCO1B1 gene was selected as the genetic instrument for single-variant MR analysis, as it was found to be less related to possible confounders than other SNPs. The association between genetic predisposition for bilirubin levels and estimated glomerular filtration rate (eGFR) or CKD was assessed in 337 129 individuals of white British ancestry from the UK Biobank cohort. Two-sample MR based on summary-level data was also performed. SNPs related to total or dire

SUBMITTER: Park S 

PROVIDER: S-EPMC9394720 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature