Unsupervised [¹⁸F]Flortaucipir cutoffs for tau positivity and staging in Alzheimer's disease.

ABSTRACT:

Purpose

Several [¹⁸F]Flortaucipir cutoffs have been proposed for tau PET positivity (T⁺) in Alzheimer's disease (AD), but none were data-driven. The aim of this study was to establish and validate unsupervised T⁺ cutoffs by applying Gaussian mixture models (GMM).

Methods

Amyloid negative (A^-) cognitively normal (CN) and amyloid positive (A⁺) AD-related dementia (ADRD) subjects from ADNI (n=269) were included. ADNI (n=475) and Geneva Memory Clinic (GMC) cohorts (n=98) were used for validation. GMM-based cutoffs were extracted for the temporal meta-ROI, and validated against previously published cutoffs and visual rating.

Results

GMM-based cutoffs classified less subjects as T⁺, mainly in the A^-

SUBMITTER: Quattrini G 

PROVIDER: S-EPMC10542510 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature