Visualization of fibroblast activation using ⁶⁸Ga-FAPI PET/CT after pulmonary vein isolation with pulsed field compared with cryoballoon ablation.

ABSTRACT:

Background

Pulsed-field ablation (PFA) is a novel ablation modality for atrial fibrillation (AF) ablating myocardium by electroporation without tissue-heating. With its different mechanism of tissue ablation, it is assumed that lesion creation is divergent to thermal energy sources. ⁶⁸Ga-fibroblast-activation protein inhibitor (FAPI) PET/CT targets FAP-alpha expressed by activated fibroblasts. We aimed to assess ⁶⁸Ga-FAPI uptake in pulmonary veins as surrogate for ablation damage after PFA and cryoballoon ablation (CBA).

Methods

26 patients (15 PFA, 11 CBA) underwent ⁶⁸Ga-FAPI-PET/CT after ablation. Standardized uptake values (SUV) and fibroblast-activation volumes of localized tracer uptake were assessed.

Results

Patient characteristi

SUBMITTER: Kupusovic J 

PROVIDER: S-EPMC10558367 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature