Effects of heart failure and coronary artery disease on erectile dysfunction: a two-sample mendelian randomization study.

ABSTRACT:

Background and aims

There are no clear conclusions as to whether heart failure (HF) and coronary heart disease (CAD) increase the risk of erectile dysfunction (ED).In our study, we used Mendelian randomization (MR) analysis to discover a causal relationship between HF, CAD and ED.

Methods

Single nucleotide polymorphisms (SNPs) associated with HF, CAD and ED were obtained from the MRC IEU Open Genome-Wide Association Study (GWAS) database.After a series of screenings, the remaining SNPs were selected as instrumental variables (IVs) for HF and CAD for MR analysis to assess the relationship between genetically predicted HF or CAD and the pathogenesis of ED.Among them, we used the random-effects inverse variance weighted (IVW) method as the primary analysis method.Finally, Cochr

SUBMITTER: Shao K 

PROVIDER: S-EPMC10576338 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature