Snoring and risk of dementia: a prospective cohort and Mendelian randomization study.

ABSTRACT:

Background

The association between snoring, a very common condition that increases with age, and dementia risk is controversial. Snoring is linked to obstructive sleep apnoea and cardiometabolic conditions, both of which are associated with an increased risk of dementia. However, snoring also increases with body mass index (BMI), which in late life is linked to lower dementia risk, possibly due to metabolic changes during prodromal dementia.

Methods

The prospective cohort study used data from 450,027 UK Biobank participants with snoring measured at baseline (2006 - 2010), and followed up for dementia diagnosis (censored at 2022). Two-sample Mendelian randomization (MR) analysis used summary statistics for genome-wide association studies of Alzheimer's disease (AD) (n = 94,43

SUBMITTER: Gao Y 

PROVIDER: S-EPMC10593011 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature