Biocompatible and bioactivable terpolymer-lipid-MnO₂ Nanoparticle-based MRI contrast agent for improving tumor detection and delineation.

ABSTRACT: Early and precise detection of solid tumor cancers is critical for improving therapeutic outcomes. In this regard, magnetic resonance imaging (MRI) has become a useful tool for tumor diagnosis and image-guided therapy. However, its effectiveness is limited by the shortcomings of clinically available gadolinium-based contrast agents (GBCAs), i.e. poor tumor penetration and retention, and safety concerns. Thus, we have developed a novel nanoparticulate contrast agent using a biocompatible terpolymer and lipids to encapsulate manganese dioxide nanoparticles (TPL-MDNP). The TPL-MDNP accumulated in tumor tissue and produced paramagnetic Mn²⁺ ions, enhancing T₁-weight MRI contrast via the reaction with H₂O₂ rich in the acidic tumor microenvironm

SUBMITTER: Yen TC 

PROVIDER: S-EPMC10832465 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature