Mendelian randomization analysis reveals an independent causal relationship between four gut microbes and acne vulgaris.

ABSTRACT:

Background

Numerous studies have suggested a correlation between gut microbiota and acne vulgaris; however, no specific causal link has been explored.

Materials and methods

To investigate the possible causal relationship between gut microbiota and acne vulgaris, this study employed a large-scale genome-wide association study (GWAS) summary statistic. Initially, a two-sample Mendelian randomization (MR) analysis was utilized to identify the specific gut microflora responsible for acne vulgaris. We used the Inverse Variance Weighted (IVW) method as the main MR analysis method. Additionally, we assessed heterogeneity and horizontal pleiotropy, while also examining the potential influence of individual single-nucleotide polymorphisms (SNPs) on the analysis results. In order to e

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10869500 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature