Epigenetic age acceleration and cognitive performance over time in older adults.

ABSTRACT:

Introduction

This study investigated whether epigenetic age acceleration (AA) is associated with the change in cognitive function and the risk of incident dementia over 9 years, separately in males and females.

Methods

Six epigenetic AA measures, including GrimAge, were estimated in baseline blood samples from 560 Australians aged ≥70 years (50.7% female). Cognitive assessments included global function, episodic memory, executive function, and psychomotor speed. Composite cognitive scores were also generated. Dementia (Diagnostic and Statistical Manual for Mental Disorders - IV [DSM-IV] criteria) was adjudicated by international experts.

Results

Associations between epigenetic AA and cognitive performance over-time varied by sex. In females only, GrimAA/Grim2AA was as

SUBMITTER: Phyo AZZ 

PROVIDER: S-EPMC11399883 | biostudies-literature | 2024 Jul-Sep

REPOSITORIES: biostudies-literature