Validation of a gene expression-based subclassification strategy for pediatric septic shock.

ABSTRACT:

Objective

Septic shock heterogeneity has important implications for clinical trial implementation and patient management. We previously addressed this heterogeneity by identifying three putative subclasses of children with septic shock based exclusively on a 100-gene expression signature. Here we attempted to prospectively validate the existence of these gene expression-based subclasses in a validation cohort.

Design

Prospective observational study involving microarray-based bioinformatics.

Setting

Multiple pediatric intensive care units in the United States.

Patients

Separate derivation (n = 98) and validation (n = 82) cohorts of children with septic shock.

Interventions

None other than standard care.

Measurements and main results

Gene expression

SUBMITTER: Wong HR 

PROVIDER: S-EPMC3196776 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature