Prognostic value of subventricular zone involvement in relation to tumor volumes defined by fused MRI and O-(2-[¹⁸F]fluoroethyl)-L-tyrosine (FET) PET imaging in glioblastoma multiforme.

ABSTRACT:

Background

Subventricular zone (SVZ) involvement is associated with a dismal prognosis in patients with glioblastoma multiforme (GBM). Dual-time point (dtp) O-(2-[¹⁸F]fluoroethyl)-L-tyrosine (FET) PET/CT (PET) may be a time- and cost-effective alternative to dynamic FET PET, but its prognostic value, particularly with respect to SVZ involvement, is unknown.

Methods

Thirty-five patients had two scans 5-15 and 50-60 min after i.v. FET injection to define tumor volumes and SVZ involvement before starting radiotherapy. Associations between clinical progression markers, MRI- and dtp FET PET-based tumor volumes, or SVZ involvement and progression-free (PFS) and overall survival (OS) were assessed in univariable and multivariable analyses.

Results

The extent of re

SUBMITTER: Harat M 

PROVIDER: S-EPMC6398237 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature